Inflammation Disease Models

Allergic Asthma
In-Vivo and In-Vitro Disease Models

Allergic Asthma:

Allergic asthma is typically triggered by allergens in the air and can be characterized by reversible airway obstruction, elevated levels of IgE causing mast cell activation, chronic airway inflammation and airway hyper-responsiveness. The immunological processes involved are characterized by proliferation and activation of Th2 lymphocytes.

The ovalbumin induced allergic asthma model is a widely used model to reproduce the airway eosinophilia, pulmonary inflammation and elevated IgE levels found during asthma. While we know that Th2 lymphocytes play an important role in the initiation, progression and persistance of allergic asthma, there is a lot to be understood about the immunoregulatory mechanisms. Combining the traditional OVA-induced allergic asthma model with an adoptive transfer of antigen specific transgenic (Tg) T cells, it is possible to dissect the role of antigen specific immune responses that contribute to pathology.

MD Biosciences In Vivo and In Vitro Models for Allergic Asthma

Type Model Description

In Vivo Ovalbumin Induced Asthma Model
This model is used to reproduce the airway eosinophilia, pulmonary inflammation and elevated IgE levels. Analysis of this model relies on general indicators of asthma such as histology and bronchoalveolar lavage analysis as well as airway hyper-responsiveness (AHR) measurements.
White Paper

In Vivo
OVA induced asthma with Tg T cells Analysis of the immune response in the traditional model is informative but entirely retrospective. Combining it with the transfer system provides information about the developing immune response.
White Paper

In Vitro
Lung Epithelial Cell Model Human lung cell line is stimulated with cytokines and analyzed for inflammatory mediators.

In Vitro
Bronchial Smooth Muscle Cell Model Human bronchial cell line is stimulated with cytokines and analyzed for inflammatory mediators.

Custom designed models and in vitro assays available. Please contact a respresentative to discuss a custom assay design.

ARTHRITIS IN-VIVO INFLAMMATORY MODELS

MULTIPLE SCLEROSIS IN-VIVO MODEL

OTHER IN-VIVO AND IN-VITRO MODELS OF INFLAMMATION

REGISTER

Type	Model	Description
In Vivo	Ovalbumin Induced Asthma Model	This model is used to reproduce the airway eosinophilia, pulmonary inflammation and elevated IgE levels. Analysis of this model relies on general indicators of asthma such as histology and bronchoalveolar lavage analysis as well as airway hyper-responsiveness (AHR) measurements.	White Paper

In Vivo	OVA induced asthma with Tg T cells	Analysis of the immune response in the traditional model is informative but entirely retrospective. Combining it with the transfer system provides information about the developing immune response.	White Paper

In Vitro	Lung Epithelial Cell Model	Human lung cell line is stimulated with cytokines and analyzed for inflammatory mediators.

In Vitro	Bronchial Smooth Muscle Cell Model	Human bronchial cell line is stimulated with cytokines and analyzed for inflammatory mediators.

Inflammation Disease Models

Allergic Asthma In-Vivo and In-Vitro Disease Models

Allergic Asthma
In-Vivo and In-Vitro Disease Models