The Collagen Antibody Induced Arthritis (CAIA) model is a rapid and synchronized alternative to the Collagen Induced Arthritis model. A cocktail of arthritogenic monoclonal antibodies to CII combined with a boost of LPS is used to induce arthritis. These arthritis inducing antibodies recognize a wide range of epitopes on the CII molecule and thereby allow formation of large immune complexes on the cartilage. Since these pre-formed antibodies are administered, the initial phase of the immune response involving T and B cell interaction is not present. This makes the model far more rapid, with onset within 48 hours of LPS boost and a total duration of as little as 10 days.
The shorter model length presents great advanatages for researchers:
- less compound required to run studies
- Synchronicity between onset of disease in animals simplifies data analysis and allows for more direct comparison between test groups.
- Susceptibility to various strains including normally CIA-resistant and transgenic strains
- Time to market: multiple studies can be run in the time it takes to run 1 CIA so you can efficiently move your compound through pre-clinical efficacy stages.
- Reduce development time by 30%
Collagen Antibody-Induced Arthritis Model
| Length |
10-18 days |
| Strains |
Balb/c, DBA/1, C57Bl/6 |
| Positive Controls |
Dexamethasone, Enbrel |
| Readouts |
Body weight, Clinical signs, Arthritis score |
| Optional measurements |
Hind paw thickness, histology, cytokine analysis, Gene expression |
| H&E Staining: Joints from Collagen Antibody Induced Arthritis (CAIA) Model (click on thumbnail images) |
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