MD Biosciences performs efficacy studies for proof-of-concept as well as assays for early screening and profiling of drug candidates. If there is a model or assay that you don't see listed, please contact a representative to discuss a custom assay design.
TNBS-induced IBD
The hapten induced model of colitis induced by intrarectal administration of colitis resembling Crohn's Disease in the distribution and location of lesions and allows the study of the early events in the initation of colitis. The pathology is driven by a potential initial IL-12 and TNF-a response, which preclude a counter regulatory IL-10 and TGF-b response.
DSS-induced IBD
This model employs dextran sodium sulpahte to induce colitis and runs for 7 days. In contract to TNBS-induced colitis, the pathology is not dependant on T cells and is therefore a more useful model to study the role of non lymphoid cells such as macrophages in induction of disease and is similar to ulcerative colitis.
Inflammatory Bowel Disease (IBD)
IBD is a common chronic gastrointestinal disorder whose incidence occurs in more than 100,000 cases per year depending on the geographical location. IBD is an umbrella term that covers a range of diseases including ulcerative colitis (UC) and Crohn's Disease, both which are chronic wasting conditions of the unknown aetiology for which there is still no cure. They are characterized clinically by diarrhea and body weight loss. Histopathological signs include leukocyte infiltration, pronounced epithelial hyperplasia, depletion of mucin secreting goblet cells and finally ulceration.