Collagen Induced Arthritis: Reagents and Assays

Peptidoglycan - Polysaccharide Polymer (PG-PS)
Streptococcus Group A Cell Wall

PG-PS 10S*				Catalog # 3036001
Size/Volume	10 mgs				View product insert
Concentration	3 - 6 mg/mL rhamnose*
Molecular Weight	5 x 106 - 5 x 108 Da				Request Quote
Application	-intraperitoneal model for spontaneously occuring acute arthritis -intramural model for gastrointestinal studies

PG-PS 100P *				Catalog # 3036002
Size/Volume	10 mgs				View product insert
Concentration	5 - 8 mg/mL rhamnose
Molecular Weight	5 x 107 Da				Request Quote
Application	-intra-articular model for experimentally induced acute & chronic arthritis

* PGPS concentrations are measured in milligrams of rhamnose per mL of material.

 

OVERVIEW

PG-PS 10S and PGPS 100P are purified peptidoglycan-polysaccharide polymers produced from Streptococcus pyogenes Group A, D58 strain. The use of these polymers in animal models induces a biphasic inflammatory response that is highly representative of that which is naturally occurring.

 

 Experimental diseases induced by PG-PS in rats:

        acute and chronic, remittent, erosive arthritis

        granulomatous enterocolitis (resembling Crohns disease)

        granulomatous hepatitis

        intestinal hemorrage

        vasculitis

Benefits:

        Ready-to-use with no special preparation

        Produces acute response observed in 3-5 days

        Consistently produces high response rates

 

 

Product inserts are for information use only.