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Inflammation Disease Models

Senerga® Mode of Action Platform
(T-and B-cell transfer model)

Senerga Mode of Action Platform

An in vivo murine model that allows for the dissection of the various steps that constitue an adaptive immune response. By dissecting this pathway, the mode of action of a compound can be determined. The platform can also be adapted to answer many other fundamental questions surrounding immunomodulation.

Central to all immune responses are the interactions of such cells as dendritic cells (DCs), T cells and B cells. In particular, the CD4+ T cell is central to many inflammatory diseases such as asthma, arthritis, IBD, and MS. It therefore follows that if we can examine the effect of a compound on the CD4+ T cell and also on DC and B cells, then we are able to observe the critical interactions that underlie the disease process of a number of diseases. Since an effective immunomodulator may act at some point along the DC, T and B cell pathway, we observe the efficacy of a potential immunomodulator and are able to choose the target disease(s) based on mode of action. 

 

 

 Type Model  Description
 In Vivo Senerga Mode of Action (T and B cell transfer)  

In vivo murine model that allows the dissection of the various steps that constitue an adaptive immune response.

   White Paper
       

 In Vitro

 T cell Activation Pathway  

A series of in vitro human an murine assays that allow for the dissection of various aspects of the innate and adaptive immune responses:

  • Antigen Presenting Cell (APC) Activation
  • APC Presentation
  • T cell activation
  • T cell proliferation
  • T cell cycle
  • T cell apoptosis
  • B cell activation
  
       

 

 

Custom assay designs are available. Please contact a representative to discuss a custom assay design.