Inflammation Disease Models

Arthritis in-vivo and in-vitro inflammatory models

Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune disease that can cause chronic inflammation of the joints and other areas of the body. RA has been estimated to affect approx. 1% of the world population. Inflammatory types of arthritis are characterized by their tendency to cause inflammation in joints and tendons. Bone and cartilage destruction is also a consequence of the inflammatory process. The cytokines IL-1 and TNF- stimulate the release of collagenase and other proteases. RA models have been developed which have proved the arthritogenic potential of cartilage autoantigens such as collagen type II and proteoglycan. These RA models all elude to the same principle: arthritis due to the loss of tolerance against a cartilage specific autoantigen. MD Biosciences evaluates the in-vivo effectiveness of anti-inflammatory agents using well-established RA disease models.

MD Biosciences Rheumatoid Arthritis Disease Models

Type Model Description

In Vivo Collagen Induced Arthritis
An in vivo murine model of arthritis where pathology is induced by type II bovine collagen.

In Vivo
Monclonal Antibody Induced Arthritis
An in vivo murine model of arthritis that utilizes the ArthritoMAB™ cocktail of 4 anti-collagen mAbs to induce a rapid and synchronized model of RA.
White Paper

In Vivo Adjuvant Induced Arthritis
A in vivo rat model where arthritis is induced by injection of CFA in the footpad.

In Vitro
Synovial Fibroblast Assay Synovial fibroblasts from OA or RA patients are tested for marker expression. Changes is marker expression along with cell migration and cartilage degradation are also measured. A comparison between diseased tissue and normal tissue is also available.

Custom designed models and in vitro assays are available. Please contact a representative to discuss a custom assay design.

ARTHRITIS IN-VIVO INFLAMMATORY MODELS

MULTIPLE SCLEROSIS IN-VIVO MODEL

OTHER IN-VIVO AND IN-VITRO MODELS OF INFLAMMATION

REGISTER

Type	Model	Description
In Vivo	Collagen Induced Arthritis	An in vivo murine model of arthritis where pathology is induced by type II bovine collagen.

In Vivo	Monclonal Antibody Induced Arthritis	An in vivo murine model of arthritis that utilizes the ArthritoMAB™ cocktail of 4 anti-collagen mAbs to induce a rapid and synchronized model of RA.	White Paper

In Vivo	Adjuvant Induced Arthritis	A in vivo rat model where arthritis is induced by injection of CFA in the footpad.

In Vitro	Synovial Fibroblast Assay	Synovial fibroblasts from OA or RA patients are tested for marker expression. Changes is marker expression along with cell migration and cartilage degradation are also measured. A comparison between diseased tissue and normal tissue is also available.