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Research Article

Neurodegenerative Disease

Oxygen Deprivation and its Effects on Cognition 

Measuring Cognitive Impairment in Oxygen Deprivation and Neurodegenerative Disease Models

Diseases of the central nervous system are extremely debilitating, increasingly common, and affect millions of people worldwide. Neurodegenerative diseases often result in a combination of cognitive and motor deficits that affect an individual’s ability to perform daily tasks. Although there are a variety of pathways leading to neurodegenerative disease, the end result is the same: loss of function in the central nervous system and resulting impairments. Many neurodegenerative disorders are progressive in nature, resulting in a decline in function that may occur over several years or several decades. While there are some treatments available for neurodegenerative disorders, there are no cures. Therefore, there is great interest in researching neurodegenerative diseases and a need to halt or slow the process of cognitive decline. Understanding the basic biological mechanism of disease and cognitive impairment is pertinent for the development of therapeutics. 


What's in this article?

  • Outcome in oxygen stress and neurodegenerative diseases
  • Distinguishing between motor function and cognition
  • Cognitive impairment in animals
  • Cognitive tests in models of oxygen stress and neuroimmunology diseases
  • Relavence of cognitive tests