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Immunotherapy, the Answer to Cancer?

Posted by MD Biosciences on Aug 30, 2016 2:46:55 PM

Immunoinhibitory checkpoints — act as the BREAKS of an immune system — shutting down the adaptive immune response. While inhibitory checkpoints such as PD-1 and CTLA-4 are important in the long-term prevention of auto-immune disorders, cancer will often take advantage of these signaling molecules to avoid destruction by the host immune system. In light of this, development of antagonistic monoclonal antibodies to block these signaling molecules has led to the FDA approval of both an anti-CTLA-4 monoclonal antibody, ipilimumab, and two anti-PD-1 antibodies, pembrolizumab and nivolumab, for the treatment of cancer.

These immunotherapeutic treatments have demonstrated versatility in the treatment of multiple cancer types. Nivolumab — first approved for the treatment of metastatic melanoma in late 2014 — has since been approved for treating advanced lung cancer and renal cell carcinoma, further illustrating the versatility of this immunotherapeutic approach. While demonstrating promise as single agents, the efficacious effects of these therapies are dramatically improved when they are used in combination with other chemo-radiation, or immuno-therapies. This exciting area of therapeutic potential is still in its infancy and continues to grow as more and more is learned about harnessing the body’s own capabilities to destroy cancer.

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Topics: cancer/tumor, Immuno-Oncology

Accelerating Academic Life Science Technology Discoveries

Posted by MD Biosciences on Jul 18, 2016 10:44:34 AM

St. Paul, Minn., June 24, 2016 - MD Biosciences launches the InnovX® research platform that’s designed to bridge the gap between preliminary, early stage and industry relevant life science product research discoveries by academic institute researchers, as well as de-risk necessary research investments.

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Topics: Academic Research, Discovery, Discoveries, InnovX

Microbiome Impact on Disease: Translational Microbiome Conference

Posted by MD Biosciences on May 6, 2016 8:15:25 AM

The 2016 Arrowhead Translation Microbiome brought the who’s who of the microbiome community together last week in the heart of Boston. Top key opinion leaders in the field came together to discuss new therapeutic discoveries, disease indications and regulatory pathways. Seres Therapeutics, the leader in microbiome therapy development, opened the meeting discussing their pipeline and recently designated “FDA Breakthrough Therapy”, Ser-109, for the treatment of reoccurring C. difficile infections. Other big players in attendance were Commense and Osel, Inc, who are both working to understand the impact of the vaginal microbiome on health and disease and how to treat a dysbiotic vaginal environment.

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Topics: Microbiome, translational

What is the Impact of Vendor Animal Microbiomes on Disease?

Posted by MD Biosciences on Apr 22, 2016 2:35:00 PM

On Thusday, MD Biosciences' Lead Scientist Britnie James, Ph.D. presented at the 2nd Annual Translational Microbiome Conference held in Boston, MA.  Her talk entitled "Understanding the Impact of Animal Vendors and the Microbiome in Tumor Progression and Treatment in a Model of Metastatic Breast Cancer" highlights the importance of the role of the micorbiome in disease progression and treatment. 

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Topics: Inflammation, cancer/tumor, Microbiome

Pig Model of Post-operative Pain- Analgesic Assessment

Posted by MD Biosciences on Jan 19, 2016 12:02:49 PM

MD Biosciences, in collaboration with PainReform Ltd and Lahav Research Institute, tested two new anesthetic formulations in the recent publication “Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs”, on which MD Biosciences’ CSO Sigal Meilin was the principal author. This article demonstrated how the pig POP model could be used to assess the efficacy of new anesthetic test compounds or new formulations. Results indicate that the tested drug formulations showed great promise over current, commercially available anesthetics.

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Topics: Pain, Neuro/CNS, post-operative pain

2015 Recap|Clinical Diagnostics & Translational Research

Posted by MD Biosciences on Dec 17, 2015 4:57:36 PM

As we wind down to years end, we at MD Biosciences would like to thank everyone, especially our collaborators, for making this year a success. We have undergone significant growth that we expect to continue throughout the upcoming year.

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Topics: Pain, Inflammation, Neuro/CNS, post-operative pain, cancer/tumor, Microbiome, Biomarkers, CLIA, Neuropathy

Cancer, CLIA & Precision Medicine | High-Quality Testing

Posted by MD Biosciences on Dec 2, 2015 2:31:26 PM

As an already fully functioning good laboratory practices (GLP) operation, MD Biosciences has recently achieved a new stage of value through CLIA certification for our high quality-testing services in the clinical and diagnostic arenas. CLIA or the Clinical Laboratory Improvements Amendments was put in place at the federal level to ensure a high level of laboratory testing. Therefore, clients can be assured that MD Biosciences meets these high quality standards and feel confident that their samples will be handled with the utmost technical and professional care to obtain reliable results.

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Topics: Personalized medicine, precision medicine, CLIA, Certification, High-quality

Pain Response in Pigs Mimics Human Pain Behavior

Posted by MD Biosciences on Nov 17, 2015 12:10:56 PM

The pig peripheral neuritis trauma (PNT) model is an important transitional model that bridges the gap between animal research and the clinic. While we discussed how the the pig PNT model shares many morphological and molecular pathology similarities with skin biopsies from human pain conditions in our poster pdf, our chief scientist was the last, principle author in a preceding publication entitled “Peripheral Neuritis Trauma In Pigs: A Neuropathic Pain Model” in the Journal of Pain. In this paper, authors examine this model in terms of how it relates to the human pain response.

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Topics: Pain, Neuro/CNS, Stress, neuropathic pain

Biomarkers Put Precision In Precision Medicine | AMP 2015

Posted by MD Biosciences on Nov 12, 2015 12:58:51 PM

The 2015 annual AMP meeting opened Novemeber 5th in Austin TX, with a presentation by Dr Brian Druker titled “Imatinib as a Paradigm of Targeted Cancer Therapies.”  This year’s recipient of the AMP Award for Excellence in Molecular Diagnostics, Dr Druker highlighted the importance of identifying patients through biomarkers and matching therapies to the patient.  This theme continued through many of the presentations, posters and vendor exhibits the importance of providing physicians actionable results for patient care and therapeutics.  Molecular diagnostics are critical to any discussion on precision or personalized medicine. 

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Topics: cancer/tumor, Microbiome, Biomarkers, Association for Molecular Pathology, Pathology, precision medicine

Join MD Biosciences for AMP 2015 Annual Meeting

Posted by MD Biosciences on Nov 2, 2015 2:30:00 PM

MD Biosciences will be attending the Association for Molecular Pathology 2015 Conference in Austen Texas on November 5-7. The conference will focus on “realizing the dream of precision medicine”. As a CLIA lab, we are looking forward to meeting with our colleagues in the diagnostic industry and discussing the latest updates in testing and treatments in cancer and infectious diseases. Additionally, we are excited to hear about the cutting edge research occurring in clinical translational medicine and pharmacogenomics. Please contact us at info-us@mdbiosciences.com if you would like to meet at the conference. Stay tuned for our blog recap of the event.

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Topics: AMP, Association for Molecular Pathology, Pathology, CLIA