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MD Biosciences Blog

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Biotechnology Advancements Illuminate Novel Treatments for Human Diseases: Weekly Highlights

Posted by MD Biosciences on Sep 11, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Health, Nature, Nature Methods and Science reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Topics: Biotechnology, preclinical research, Metastatic tumor

Biomarkers, Drug Discovery and Immunotherapy: Weekly Highlights

Posted by MD Biosciences on Sep 6, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Nature, Nature Communications and Cell, reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

                                                                                     image source: wildpixel/Getty Images
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Topics: preclinical research, Discoveries, Life Science, cancer/tumor, Biomarkers

From stem cells to mushrooms: the latest scientific discoveries and technological advances

Posted by MD Biosciences on Aug 28, 2018 9:39:28 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals and sites including Science Translational Medicine, SciWorthy, ScienceDaily, Science, Gen News, Frontier Pharmacology and American Journal of Pathology, reporting innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

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Animal Models of Allergic Asthma: Utilities and Limitations

Posted by MD Biosciences on Aug 16, 2018 10:00:00 AM

Allergic asthma is a chronic inflammatory disease characterized by airway inflammation, changes in structural activity, and bronchial hyperactivity. Scientists have tried to mimic such features of human allergic asthma in murine models as the prevalence of asthma in westernized countries has nearly doubled over the last 20 years to an estimated 180,000 asthma-related deaths per year (WHO, 2018). To date there is no cure for asthma; treatment efforts including inhalers, diet intervention and steroidal injection are designed for symptom relief (Roland et al., 2018). Other initiatives include electronic health recording (EHR) allowing patients to co-manage disease in between office visits. Such interventions and therapies are temporary, aiming to minimize severity of symptoms and number of office visits but they do not always alter underlying pathological mechanisms. Thus, suitable efficacy models are needed. The Ovalbumin (OVA) and House Dust Mite (HDM)-induced models are widely-used models to explore underlying pathogenesis of asthma and MD Biosciences is proud to offer both  models as resources for testing new therapeutics as well as provide additional ex vivo assessment services to better understand therapeutic method of action.

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Topics: preclinical research, asthma, efficacy, Models, Discoveries, Life Science, Biomarkers

IL-33 and T1/ST2 Function in Wound Healing and Inflammatory Responses

Posted by MD Biosciences on Aug 7, 2018 2:19:52 PM

IL-33 is a member of the IL-1 cytokine family with a widely-recognized inflammatory role in a broad range of skin diseases. It functions as a signaling ligand for the T1/ST2 receptor, also known as IL1RL1, T1 and IL-33R (Palmer and Gabav, 2011). Expression of IL-33 occurs in the nucleus of epithelial and endothelial cells and has been labeled as an “alarmin”—an immunological alarm signaled during cellular distress or cellular necrosis in mammals. Interestingly, recent reports indicate distinct species differences between mice, humans and pigs, prompting further comparative studies. In some murine epidermis models, prominent constitutive IL-33 expression was seen in epidermal keratinocytes and was drastically lost in basal keratinocytes during acute inflammatory events, while other studies observed a drastic increase in IL-33 during inflammatory events (Sundes et al., 2015). The loss of IL-33 from keratinocyte nuclei could be due to protein degradation or another release mechanism not yet identified. In contrast to the prominent constitutive IL-33 expression in murine keratinocytes, IL-33 signal was substantially low in human epidermis, demonstrating weak signals in the nuclei of keratinocytes. The classification as an alarmin is suitable for murine models but may not be as accurate for humans and pigs. 

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MDB Neuropathic Pain Porcine Model Publication Featured in Neurobiology of Pain Journal

Posted by MD Biosciences on Jul 31, 2018 10:00:00 AM

MDB Scientists recently published a paper titled “Human-like cutaneous neuropathologies associated with a porcine model of peripheral neuritis: a translational platform for neuropathic pain”, and has been accepted to appear in the Neurobiology of Pain Journal effective July of 2018.

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Topics: translational research, Discoveries, neuropathic pain

Behavioral Research Assessments & Applications: Quantify Cognitive, Emotional, Sensory & Motor Functions

Posted by MD Biosciences on Jul 24, 2018 9:00:00 AM

Neurological diseases often result in a combination of motor and cognitive deficits. Thus, behavioral assessments in conjunction with physiological readouts offer a broader understanding of the basic biological mechanism of disease and cognitive impairment, highly relevant to therapeutic developments. Utilizing rodent and pig models, MD Biosciences offers a variety of behavioral assessment capabilities applicable to (but not limited to) the following subject areas:

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Topics: Behavioral Research, murine model, porcine model, preclinical research

Evidence Mounts for the Role of Inflammation and Immune Dysregulation in Metabolic Liver Disease Related to Obesity

Posted by MD Biosciences on Jul 19, 2018 9:30:00 AM

Over the past couple of decades, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) have become the number one cause of liver disease in Western countries. Recent data confirm that NAFLD and NASH play an equally important role in the Middle East, Far East, Africa, the Caribbean, and Latin America. The prevalence of NAFLD/NASH continues to increase along with its associated risk factors, including metabolic disorder, obesity, diabetes and hypertension. Therefore, understanding the mechanism of these diseases has become a priority. Recent investigations into the effect of chronic liver inflammation have shed light on the role of both the adaptive and innate immune systems in both NAFLD and NASH. Long suspected to play a part in such metabolic disorders along with nutrition and hormonal imbalances, the immune system has been of great interest to researchers for development of specific drug targets to maximize glucose regulation, minimize inflammatory damage to tissues and prevent the development of fibrosis that can lead to liver failure.

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Topics: fibrosis, preclinical research, murine model, Pathology, metabolic, Inflammation

Fibrotic Disease Focus: Scleroderma

Posted by MD Biosciences on May 17, 2018 11:41:03 AM

 

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Topics: fibrosis, scleroderma, drug development, translational research, preclinical research, disease models

Glatiramer Acetate (Copaxone® Generics) and Batch Release Testing in MS/EAE at MD Biosciences

Posted by MD Biosciences on Jan 31, 2018 1:45:56 PM

 

MDB Gains OECD-GLP certification for In Vivo Glatiramer Acetate Batch Release Testing Services

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Topics: Multiple Sclerosis, Generics, Batch Release Testing, Biological Equivalence Assays