The management of post-operative pain is a challenge for both physicians and patients. In addition to a comfortable recovery, the prevention of chronic pain and improvement of conventional outcomes are important in post-operative pain management.
The rat plantar incisional model (brennan) has been a popular model for post-operative pain research. It offers researchers the ability to examine the wound healing process, local and systemic inflammatory responses, neurophysiological changes in primary afferents and dorsal horn neurons and te effects of potential new therapeutics. While the rat plantar incisional model continues to provide valuable data, the development and assessment of topical and local treatment methods in this model is limited.
Pigs are comparable to humans in a number of ways that make them a better choice than rodents when modeling particular aspects of post-operative pain. The skin of pigs is relatively hairless and is structurally similar to humans in terms of epidermal thickness, fixed nature of subcutaneous layer, patter of cutaneous blood flow and immune cells that localize to the skin. Pigs have become a standar model of the wound healing process because of similarities to the human wound healing including re-epithelialization rather than contraction. These qualities allow researchers to simultaneously examine wound healing and pain evaluation in order to gain a better understanding of interactions between the processes.
For this reason, we have developed a model of post-operative pain based on the benefits of the Brennan rat model but with a closer approximation to human physiology, anatomy and metabolism.
Benefits of the pig as a model of post-operational pain:
Contact us to discuss a relevant study for post-operative pain or download the whitepaper to learn more about the model.