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MD Biosciences Blog

Biomarkers, Drug Discovery and Immunotherapy: Weekly Highlights

Posted by MD Biosciences on Sep 6, 2018 10:00:00 AM

MD Biosciences providing up-to-date news coverage compiling posts from science journals including Nature, Nature Communications and Cell, reporting fascinating and innovative discoveries happening all over the world across a wide variety of disciplinary areas. Skim the titles below to catch up on what is happening and to learn what the team at MD Biosciences is reading about. Follow the links to read more about something that catches your eye! 

                                                                                     image source: wildpixel/Getty Images
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Topics: preclinical research, Discoveries, Life Science, cancer/tumor, Biomarkers

Animal Models of Allergic Asthma: Utilities and Limitations

Posted by MD Biosciences on Aug 16, 2018 10:00:00 AM

Allergic asthma is a chronic inflammatory disease characterized by airway inflammation, changes in structural activity, and bronchial hyperactivity. Scientists have tried to mimic such features of human allergic asthma in murine models as the prevalence of asthma in westernized countries has nearly doubled over the last 20 years to an estimated 180,000 asthma-related deaths per year (WHO, 2018). To date there is no cure for asthma; treatment efforts including inhalers, diet intervention and steroidal injection are designed for symptom relief (Roland et al., 2018). Other initiatives include electronic health recording (EHR) allowing patients to co-manage disease in between office visits. Such interventions and therapies are temporary, aiming to minimize severity of symptoms and number of office visits but they do not always alter underlying pathological mechanisms. Thus, suitable efficacy models are needed. The Ovalbumin (OVA) and House Dust Mite (HDM)-induced models are widely-used models to explore underlying pathogenesis of asthma and MD Biosciences is proud to offer both  models as resources for testing new therapeutics as well as provide additional ex vivo assessment services to better understand therapeutic method of action.

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Topics: preclinical research, asthma, efficacy, Models, Discoveries, Life Science, Biomarkers