MD Biosciences Preclinical services utilizes a variety of in vitro cell based screening assays to investigate the effects of test compounds on inflammatory cytokine production. In addition to the models outline below, MD Biosciences can work with a sponsor to develop a cell-based assay to obtain relevant, study-specific results. Please inquire if the cell based screening assay you are looking for is not listed here.

Inflammation Related Compound Profiling Assays
LPS-stimulated human PBMC Assay
LPS-stimulated mouse Macrophage Assay
LPS-stimulated human Neutrophil Assay
Endotoxin-stimulated human differentiated Monocyte Assay
Endotoxin-stimulated human Monocyte Cell Line Assay
T cell Activation Assay
Cytokine Stimulated human Colon Adenocarcinoma Assay
Calcium Flux
Cytokine-Stimulated human Lung Epithelial Cell Assay
Cytokine-Stimulated Bronchial Smooth Muscle Cell Assay
Cytokine-Stimulated Synoviocyte Assay
Cytokine-Stimulated Keratinocyte Assay
Leukocyte Migration Assay
Endothelial Cell Adhesion Assay
Integrin Mediated Adhesion Assay
Neutrophil Chemotaxis Assay
Respiratory Burst Assay
Neutrophil Degranulation Assay

Cell Signaling Pathway Screening Assays
NF-kB Reporter Assay in Jurkat Cells
Stable Luciferase Reporter Assay

Enzyme Inhibition Assays
Indirect COX-2 Activity Assay
iNOS Activity Assay
iNOS Induction Assay
Enzyme Inhibitor Screening Assay

Calcium Flux Assays
Histamine-stimulated Calcium Flux
UTP-stimulated Calcium Flux

Adaptive Immune Response Assays
T cell Activation Assay
Antigen Presentation Assay
T cell Proliferation
B cell Proliferation
Determination of Clonal Expansion (ex vivo)
Activation Marker Expression Assay (ex vivo)
Cell Division Assay (ex vivo)
Restimulation Assay (ex vivo)
Cellular Cytokine Producton (ex vivo)
Th1/Th2/Th17/Treg Screening Assay

Medical Device Screening Assays
Human Endothelial Cells grown on stent/stent material
Contact Dependant/Independant Assay