MD Biosciences cell based assay services

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Preclinical Compound Profiling Assays: By Cell Type

MD Biosciences Pre-clinical services utilizes a variety of in vitro efficacy models to investigate the effects of test compounds on inflammatory cytokine production. In addition to the models outlined below, MD Biosciences can work with a sponsor to develop a cell-based assay to obtain relevant, study-specific results. 

Please inquire if the cell based assay you are looking for is not listed in the cell type of interest.

Monocytes/Macrophages
Endotoxin-stimulated human PBMC Assay
Endotoxin-stimulated human Differentiated Monocyte Assay
Endotoxin-stimulated human Monocyte Cell Line Assay
Endotoxin-stimulated mouse Macrophage Cell Line Assay
Indirect COX-2 Activity Assay
iNOS Activity Assay
iNOS induction assay
Leukocyte Migration Assay
Endothelial Cell Adhesion Assay
Integrin-Mediated Adhesion Assay
Medical Device Screening Assay
Calcium Flux Assay

Neutrophils/Granulocytes
Cytokine Release Assay
Degranulation Assay
Respiratory Burst Assay
Neutrophil Chemotaxis Assay
Neutrophil-Endothelial Cell Adhesion
Integrin-Mediated Adhesion Assay

T cells
Leukocyte Migration Assay
NF-kB Reporter Assay (Jurkat Cells)
T cell activation assay

Endothelial Cells
Medical Device Screening Assay
Neutrophil-Endothelial Cell Adhesion

Epithelial Cells
Cytokine-stimulated human Lung Epithelial Cell Assay
Cytokine-stimulated Keratinocyte Assay
Stable Luciferase Reporter Assay
Cytokine Stimulated Human Colon Adenocarcinoma Cell Assay

Bronchial Smooth Muscle Cells
Cytokine-stimulated Bronchial Smooth Muscle Cell assay
Calcium Flux

Synoviocytes
Cytokine-stimulated Synoviocyte Assay

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Client Testimonial

“Among all the CROs that I have used over the years, including recently for inflammation, MD Biosciences has been one of the very best in terms of scientific knowledge, expertise, data quality, timelines, flexibility and personal contacts.”

O.B., Director of Preclinical Research Pharmaceutical Company