Preclinical Contract Services

Cancer Research

Immune Oncology

Syngeneic mouse modeling for immunotherapy development

Our team of scientists possesses extensive experience in various cancer models and specializes in murine solid tumors for both subcutaneous and orthotopic models, with an emphasis on disease progression, biomarkers and immunophenotyping. 

Some examples of our syngeneic models include:

  • 4T1 metastatic breast cancer is a syngeneic breast cancer model performed in immunocompetent BALB/c mice.
  • Renca kidney cancer is a syngeneic, mouse model of metastatic renal cell carcinoma (RCC) that is modeled in BALB/c mice.
  • Lewis lung cancer (LLC) is a syngeneic, model of lung carcinoma in immunocompetent C57BL/6 mice.

We are able to put any cancer model in place and investigate all immunological and related biomarkers in addition to all cancer-related parameters. Studies to identify the impacts of co-morbidities such as obesity or compounding factors such as the micro biome can be customized.

 

Specialty research areas include:

  • Longitudinal tumor monitoring
  • Longitudinal blood phenotyping (immune cell distribution, biomarkers, etc.)
  • End time-point primary tumor evaluation and metastatic tissue evaluation (for some models)
  • Tumor tissue-specific cellular analysis using intravascular staining (cells: epithelial, endothelial, immune etc.)
  • Cancer biomarker analysis in tumor tissues
  • Biomarker development and analysis (blood, tumor tissue, spleen, lymph node etc.)
  • Histological grading and evaluation of tumor specific tissue (H&E, IHC, etc.)
  • Disease super-imposition

Highlight: The Renca Renal Cancer Model

A metastatic model to study novel immunotherpeutic approaches                                          

Novel immunotherapeutic approaches have shown efficacy in human renal cell carcinoma (RCC), demonstrating an exciting area of therapeutic potential for this cancer. Renca kidney cancer is a syngeneic, mouse model of metastatic renal cell carcinoma (RCC) in BALB/c mice. Renca cells can be injected subcutaneously or orthotopically. In the orthotopic model, cells are introduced directly into the kidney, wherein they form tumors that metastasize to secondary organs such as the lungs.

Download our datasheet for more information on the Renca model.

 

Contact Us to receive our presentation of results, discuss your interests and to find out how MD Biosciences expertise could help you obtain your research success.                                  (1-888-876-3246) or +41-44 986-2628)

 

 

 

Model Categories

  • Subcutaneous
  • Orthotopic
  • Metastatic
  • Syngeneic
  • Xenograft
Request Study Proposal

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