IL-23 induced Psoriasis efficacy studies

Recent research in psoriasis has been focused on the IL-23/Th17 pathway. IL-23 stimulates and promotes differentiation of Th17 cells. IL-23 is a heterodimeric cytokine with two subunits. It drives the TH17 response by its binding and signalling through its receptor subunits. When the IL-23R is activated, it promotes the development of TH17 cells and the resulting production of cytokines such as IL-17A, IL-17F, and IL-22 - all which are involved in mediating psoriasisform changes.
 
The IL-23 induced psoriasis model involves the injection of IL-23 into the ear of C57Bl/6 and is dependent on IL-22 for the development of dermal inflammation and acanthosis. IL-22 induces keratinocyte proliferation and epidermal hyperplasia contributing to epiderma thickening.
 

Assessments:

  • Clinical Score
  • Ear Thickness
  • Biomarker analysis (protein or mRNA)
  • Cell Populations in Spleen/Lymph Node by FACS
  • Histology/IHC
  • PK blood collections

 

SPECIES AVAILABLE:

  • mouse IL-23

 

 


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