preclinical CRO, inflammation and autoimmune disease models, dermal models, psoriasis

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IL-23 induced Psorasis

Recent research in psoriasis has been focused on the IL-23/Th17 pathway. IL-23 stimulates and promotes differentiation of Th17 cells. IL-23 is a heterodimeric cytokine with two subunits. It drives the TH17 response by its binding and signalling through its receptor subunits. When the IL-23R is activated, it promotes the development of TH17 cells and the resulting production of cytokines such as IL-17A, IL-17F, and IL-22 - all which are involved in mediating psoriasisform changes. 

The IL-23 induced psoriasis model involves the injection of IL-23 into the ear of C57Bl/6 and is dependent on IL-22 for the development of dermal inflammation and acanthosis. IL-22 induces keratinocyte proliferation and epidermal hyperplasia contributing to epiderma thickening.

  • Length of model is 21 days
  • Measurements: psoriasis score, ear thickening
  • Options: histology and biomarkers
Figure 1 Ear thickness:
IL 23 induced psoriasis ear thickness preclinical services CRO resized 600

 

Figure 2 Psoriasis Score:

IL 23 induced psoriasis preclinical services lab CRO resized 600