Dermatological Modeling for Inflammatory and Autoimmune Diseases of the Skin
Passive Cutaneous Anaphylaxis (PCA) is an immediate dermal response to an allergan-IgE interaction. It is based on a passively transferred anaphylactic reaction from antiserum. Subjects are sensitized with antiserum and following a latent period, subjects are injected IV with Evans blue dye bound to the antigen. Reaction of the antigen with skin-fixed antibody causes the release of histamine, which increases vascular permeability, permits leakage of the albumin -bound dye, and produces a blue spot at the site of the intradermal injection.