Passive Cutaneous Anaphylaxis

Passive Cutaneous Anaphylaxis (PCA) is an immediate dermal response to an allergan-IgE interaction. It is based on a passively transferred anaphylactic reaction from antiserum. Subjects are sensitized with antiserum and following a latent period, subjects are injected IV with Evans blue dye bound to the antigen. Reaction of the antigen with skin-fixed antibody causes the release of histamine, which increases vascular permeability, permits leakage of the albumin -bound dye, and produces a blue spot at the site of the intradermal injection.  

 

Assessments:

  • Dye extravasation (mm)
  • Absorbancy of Evans Blue
  • Biomarker analysis (protein or mRNA)
  • PK blood collections

 

SPECIES AVAILABLE:

  • mouse PCA
  • rat PCA

 

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