Preclinical Contract Research

Wound Healing

Dermal Wound/Inflammation/Pain

Skin Wound Healing & Inflammation


MD Biosciences talented scientific team possess many years of experience evaluating wound healing therapies, with particular expertise in wound healing studies in the pig.

Skin wound healing is a complex biological process activated by signalling pathways of epithelial and non-epithelial cells, which release a myriad of cytokines and growth factors. Rodent models of full thickness incisions comprise a large portion of preclinical wound healing research, however there is a fairly low correlation between the healing process of rodents and that of man. It has been shown however that larger species such as the pig have up to 78% correlation to human wound healing. Therefore, the pig is the ideal species for wound healing studies due to the many similarities between pig and human skin and offers great advantages in wound healing research. 
 
MD Biosciences offers various models of wound healing in both rodents and pigs. While rodents provide data for earlier research stages, the pig model is ideally suited for wound healing efficacy studies. Perhaps one of the most compelling argument for using pig for wound healing is the similarity in the physiological process through which pig and human heal. Pig and human close partial-thickness wounds primarily through re-epithelialization, rather than wound contraction as is the case with small animals such as rodents. Impaired Wound healing can also be evaluated by using a diabetic animal.

Applying FDA approved clinical tools in translational wound assessment

Traditional methods of wound healing measurement have inherent limitations. Measurements are affected by many variables including inter-personnel variability, inter-technique variability, inter- and intra-wound variability and wound changes over time. To overcome these obstacles MD Biosciences has validated and integrated the Silhouette Star system (Aranz Medical), a highly translational 3-D digital wound assessment device that, together with its proprietary software, allows our scientists to accurately image and quantify wound dimensions and track them over time. The accuracy of the system is within 2% for area, 1% for perimeter and 5% for depth or volume (Aranz Medical). The system is approved by FDA for clinical use, giving additional confidence to the results from the translational studies. In large animal trials at MD Biosciences, the Silhouette Star was found to generate wound healing data with very tight error bars.

Talk to the experts at MD Biosciences to learn how the newest technologies could be used in your studies as well.

 

Wound Types Assessments
Full skin thickness incisional Wound Score and imaging
Skin & Muscle  Inflammation Score
Excisional Gross Pathology
Heat Burn* Histology
UV Burn* IHC
  Biomarkers


 * Models currently planned for co-development. Please contact us for co-development opportunities.


Don't see the model or assessment you require? Our scientists are experienced with rapidly validating models from the literature. Please speak with a scientist to discuss your requirements. 

 

SPECIES AVAILABLE:

  • mouse incisional wound
  • rat incisional wound
  • rodent burn wound*
  • pig incisional wound
  • pig excisional wound
  • pig burn wound*

 

Request Study Proposal

 

preclinical models of wound healing: full-thickness incisional and excisional

 


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