Choosing suitable Behavior Tests for common Drug Classes
Choosing suitable behavior tests for common drug classes based on the primary mechanism and site of action.
Pain is a complex and generally unpleasant experience that serves the important protective function of alerting us to situations that may threaten our well being. As such, pain is typically associated with noxious stimuli, events that are potentially or actually damaging to tissue. Pain processing begins with specialized sensory neurons called nociceptors that are able to distinguish and preferentially respond to noxious stimuli. Nociceptive primary afferent neurons receive information via free nerve endings at their peripheral terminals and pass that information to second order neurons in the dorsal horn of the spinal cord. This first synapse in the pain pathway is one of the most targeted sites for analgesic drugs. From here, several ascending pathways exist to relay messages related to arousal as well as affective and other aspects of pain.
This eBook covers the following drug classes
Cannabinoid and receptor agonists
Cation Channel Blockers
Excerpt from the eBook:
"Pain medications can provide relief either through targeting sensitizing agents or by inhibiting the activity of neurons involved in pain processing direct- ly. This article will review several of the most commonly employed pain drug classes, their primary mechanism and site of action, and which behavioral tests are best suited to test novel compounds from each of these drug classes. "