Pain Processing & Pathways

Choosing suitable Behavior Tests for common Drug Classes

Choosing suitable behavior tests for common drug classes based on the primary mechanism and site of action.

Pain is a complex and generally unpleasant experience that serves the important protective function of alerting us to situations that may threaten our well being. As such, pain is typically associated with noxious stimuli, events that are potentially or actually damaging to tissue. Pain processing begins with specialized sensory neurons called nociceptors that are able to distinguish and preferentially respond to noxious stimuli. Nociceptive primary afferent neurons receive information via free nerve endings at their peripheral terminals and pass that information to second order neurons in the dorsal horn of the spinal cord. This first synapse in the pain pathway is one of the most targeted sites for analgesic drugs. From here, several ascending pathways exist to relay messages related to arousal as well as affective and other aspects of pain.

 

This eBook covers the following drug classes
  • Cannabinoid and receptor agonists
  • FAAH inhibition
  • ARs/TCAs
  • Opioids
  • NSAIDs
  • Cation Channel Blockers
  • TRPV1

pain-eBook