Tools and technology for CNS pain models
Utilizing the DANTEC Keypoint Focus tool engineered for precise diagnostic accuracy in measuring electrophysiology action potentials has allowed our scientists to expand our Electrophysiology (EP) services and available animal models. As one of the few laboratories in the world with these EP measurement capabilities, we can measure nerve regeneration, degeneration and protection in response to various treatments as well as non-rodent species application including our pig translational models. Application of these capabilities to EAE and MS models, peripheral nerve injury, spinal cord injury and CNS pain models provide valuable information into multiple areas of compound efficacy.
MOG EAE Model (Example of Motor Action Potential Assessment)
Peripheral Nerve Injury (Example of Muscle Action Potential Assessment)
A schematic presentation of cMAPs (A. Graphic presentation of action potential and the parameters that are recorded (i.e. amplitude; peak to peak, onset latency and duration; B. Schematic presentation of recording from normal (top) and injured nerve (bottom)