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Neurology Disease Models

Gliosis

Gliosis is a proliferation of astrocytes in the central nervous system (CNS) in response to injury which results in scar formation. Astrocytes react to injury by hypertrophy and up-regulation of the glial-fibrillary acidic protein. Gliosis, along with neuronal loss, is a prominent feature of many diseases of the central nervous system, including Alzheimer's Disease, Multiple Sclerosis, and stroke.

MD Biosciences Gliosis In-vivo Model

 Type Model  Description
 In Vivo LPS-induced Glia Cell activation model  

Gliosis is induced using LPS. Readouts: IHC analysis of number of activated microglia cells and activated astrocyte cells at the level of hippocampus.

 

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Custom designed models and in vitro assays available. Please contact a representative to discuss a custom assay design.