Preclinical Contract Research

ImmuneProfiler

Evaluate therapeutic effect on the immune response and specific pathways.

In vivo and in vitro assays for evaluating the immunosuppression or immunogenicity properties of compounds.

ImmuneProfiler is a suite of assays that can be customized to determine a compounds properties on the immune response. We offer a variety of in vivo models and in vitro assays for evaluating select pathways. Sponsors can select pathways of interest, choose between stimulation or inhibition assays, evaluate in cell based or whole animal systems. Readouts include specific cytokine panels and FACs analysis that are relevant to the pathways being evaluated. Among others, we investigate Th1, Th2, Th17, CD8 and B-cell response in vivo. In vitro methodologies and efficacy testing look at macrophage and T-cell inhibition and stimulation, proliferation and cytokine release. The tables below outline the various models and read-outs. All studies are performed in state of the art laboratories with established and validated methodologies benefitting from years of experience.

 

In vivo and in vitro assays for efficacy testing and the evaluation of immunosuppression or immunogenicity properties of compounds.

 

In Vivo Immune Response Models:

Category Species Response Output
Cellular Immunity mouse Th1 response cytokine panel, FACS
Cellular Immunity mouse Th2 response cytokine panel, FACS
Cellular Immunity mouse Th17 response cytokine panel, FACS
Cellular Immunity mouse CD8 T cell response cytokine panel, FACS
Non-specific Immunity mouse innate cytokine panel, FACS
Humoral Immunity mouse B cell response FACS, cytokines
Humoral Immunity mouse B cell activation FACS
Allergy/Hypersensitivity mouse/rat Th1 cytokines, FACS 
Allergy/Hypersensitivity mouse Th2 cytokines, FACS 

 

In Vitro Immune Response Assays

Pathway System Stimulant Output
Th17 activation PBMC antiCD3 cytokine panel, FACS
T cell inhibition PBMC antiCD3/CD28, ConA, PHA cytokine panel, FACS
T cell stimulation PBMC sponsor compound cytokine panel, FACS
Cytokine Release PBMC sponsor compound cytokine panel, FACS
Macrophage (Inhibition) PBMC LPS cytokine panel, FACS
Macrophage (stimulation) PBMC sponsor compound cytokine panel, FACS
Proliferation - (stimulate) PBMC sponsor compound CFSE
Proliferation - (inhibition) PBMC anti-CD3/CD28, ConA, PHA CFSE

 


CONTACT US:

1-888-876-3246
+41-44 986-2628
email us


 

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