View Assays by cell type or by assay type
In vitro profiling of anti-inflammatory properties
Cytokine and cell based assays are quick and provide the ability to interpret and predict many biological properties of potential drug compounds. Cytokines and related molecules have been implicated in inflammatory diseases such as rheumatic disease, multiple sclerosis, asthma, inflammatory bowel disease, and autoimmune diseases as well as cancer and infectious diseases. These assays provide the ability to determine a potential compounds affect on cell proliferation, cytokine production and cellular responses.
MD Biosciences uses a number of primary and immortalized cell lines to assay test compounds for their effect on inflammatory mediator production, signal transduction pathway activation, transcription factor activity, gene expression and other specialized assays. Using these in vitro assays, compounds can be rapidly and cost effectively screened for activity prior to more expensive and time consuming in vivo analysis.
ImmuneProfilerTM - Human Peripheral Blood Leukocyte Assays
A series of assays that can be used to better characterize the anti-inflammatory activity of a compound. Whole blood contains a number of immune cells such as monocytes, T cells, B cells and neutrophils. WIth ImmuneProfilerTM we can concentrate on a single cell type by altering whole blood fractionation and/or by changing the stimulant.
Using this series of assays, you can screen a compound through multiple systems or screen multiple compounds through one system looking at:
- Monocyte/Macrophage Response
- T cell Response
- Neutrophil Function
In vitro Assays are available using primary cells or immortalized cell lines for the following categories:
- General Inflammation Cell Based Assays
- Cell Signaling Pathway Screens
- Enzyme Inhibition Assays
- Calcium Flux Assays
You can search a wide portfolio of assays either by cell type or by assay type.