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Preclinical Laboratory Services

Collagen Antibody-Induced Arthritis Model

Rapid, Synchronized Arthritis Induction Bypassing Humoral Response

The Collagen Antibody-Induced Arthritis (CAIA) model is a rapid and synchronized alternative to the Collagen-Induced Arthritis (CIA) model. A cocktail of arthritogenic monoclonal antibodies to Collagen-II, combined with a immunogenic boost of LPS, rapidly induces arthritis in Balb/c mice. These arthritis-inducing antibodies recognize a wide range of epitopes on the Collagen-II molecule and thereby allow formation of large immune complexes within cartilage. Because these anti-collagen targeting antibodies are administered directly, the CAIA model bypasses the need for development of a humoral response against collagen involving T and B cell interactions. This allows for a far more rapid induction of disease, with onset occuring within 48 hours of the LPS boost and a total study duration of as little as 10 days.
 

CAIA Study Details:

  • Length: 10-18 days
  • Dosing Paradigms: Prophylactic (developing or semi-established)
  • Dosing routes: PO, IP, SC, IV, Infusion pump
  • Controls: Dexamethasone, Enbrel
  • Assessments: Arthritis Score, Hind paw thickness, Body weight

 

Optional Assessments:

  • Circulating or tissue level Biomarker analysis (protein or mRNA)
  • Histological/IHC assessment of joints
  • PK blood collections
  • Cell populations in the spleen/lymph node by FACS

 

Paw Thickness in the CAIA Model

CAIA_Balbc_paw_thickness.png

Representative data from the Collagen Antibody-induced Arthritis (CAIA).

Paw thickess over 12 days in Balb/c animals treated with vehicle, Enbrel or Dexamethasone.

SPECIES AVAILABLE

  • Mouse CAIA
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collagen antibody-induced arthritis (CAIA)

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