Preclinical Research

Collagen Antibody-induced Arthritis

Inflammation/Autoimmune DIseases

Collagen Antibody-induced Arthritis (CAIA)

The Collagen Antibody Induced Arthritis (CAIA) model is a rapid and synchronized alternative to the Collagen Induced Arthritis model. A cocktail of arthritogenic monoclonal antibodies to CII combined with a boost of LPS is used to induce arthritis. These arthritis inducing antibodies recognize a wide range of epitopes on the CII molecule and thereby allow formation of large immune complexes on the cartilage. Since these pre-formed antibodies are administered, the initial phase of the immune response involving T and B cell interaction is not present. This makes the model far more rapid, with onset within 48 hours of LPS boost and a total duration of as little as 10 days.

CAIA Study Details:

  • Length: 10-18 days
  • Dosing Paradigms: Prophylactic (developing or semi-established)
  • Dosing routes: PO, IP, SC, IV, Infusion pump
  • Controls: Dexamethasone, Enbrel
  • Assessments: Arthritis Score, Hind paw thickness, Body weight


Optional Assessments:

  • Circulating or tissue level Biomarker analysis (protein or mRNA)
  • Histological/IHC assessment of joints
  • PK blood collections
  • Cell populations in the spleen/lymph node by FACS



  • mouse CAIA


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collagen antibody-induced arthritis (CAIA)



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