The Collagen Antibody Induced Arthritis (CAIA) model is a rapid and synchronized alternative to the Collagen Induced Arthritis model. A cocktail of arthritogenic monoclonal antibodies to CII combined with a boost of LPS is used to induce arthritis. These arthritis inducing antibodies recognize a wide range of epitopes on the CII molecule and thereby allow formation of large immune complexes on the cartilage. Since these pre-formed antibodies are administered, the initial phase of the immune response involving T and B cell interaction is not present. This makes the model far more rapid, with onset within 48 hours of LPS boost and a total duration of as little as 10 days.
CAIA Study Details:
Length: 10-18 days
Dosing Paradigms: Prophylactic (developing or semi-established)
Dosing routes: PO, IP, SC, IV, Infusion pump
Controls: Dexamethasone, Enbrel
Assessments: Arthritis Score, Hind paw thickness, Body weight
Circulating or tissue level Biomarker analysis (protein or mRNA)