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Preclinical Laboratory Services

DSS-Induced IBD Model

Preclinical Models for Pharmacology and Efficacy Studies

DSS-induced Model For Studying Inflammatory Bowel Disease (IBD) 

Our DSS model is a chemically-induced study of Inflammatory Bowel Disease (IBD) using dextran sodium sulphate (DSS) in drinking water that induces ulcerative colitis-like inflammation. And the disease is descending colon specific characterized by; gross bleeding, thickened colon walls with occasional adhesions, pseudo polyps, redness and edema, as well as reduced overall colon length. 
  • For Acute Colitis models - we induce a continuous administration of DSS over the course of 5 days.
  • For Chronic Colitis models - we induce by administering DSS in sterile drinking water in alternating cycles.
Our model is extremely useful for studying the role of innate leukocyte cells such as macrophages and neutrophils in induction of disease, because the pathology of the DSS IBD model involves general innate inflammation. In addition, a one-time i.p. injection of anti-p40 anitbody significantly reduces disease severity.
  • The Acute DSS model is available in mice and rats.
  • The Chronic DSS model is available only in mice.

 Speak to a scientist about your study requirements and any options not listed below.

Dosing Routes: Assessments available:
PO Body weight loss
IV Colitis score
IP Colon length/weight
SC Gross Pathology
Infusion Pump Biomarkers
Cannula Histology/IHC


Colitis Score in the Acute DSS Model

DSS Clinical Colitis Score.jpg

C57Bl/6 were administered DSS in the drinking water for 5 days. Over the course of 10 days, colitis score was monitored in animals receiving DSS (Blue), no DSS (Black) and DSS + Positive Control (Red)

Species Available: 

Mouse Acute DSS

Mouse Chronic DSS

Rat Acute DSS

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