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Preclinical Laboratory Services

LPS-Induced Acute Lung Injury

Validated Model For Respiratory Inflammation Studies


LPS-Induced Lung Inflammation/Acute Lung Injury (ALI)

LPS lung inflammation models are widely used to study host-response patterns in the pulmonary compartment. The LPS lung inflammation model is an acute lung inflammation model where researchers can observe the pulmonary response following exposure to bacteria. Following induction by the intranasal administration of LPS,  leukocytes (mainly neutrophils) are recruited to the lung within 4 hours. Using this model, it is possible to measure and characterize the cellular profile of recruited leukocytes to the lung airways as well as the levels of pro-inflammatory cytokines.



  • Cell populations in the BALF by FACS
  • Cytokine profile in BALF or lung tissue by multiplex
  • WBC
  • Total Protein
  • Histology

TNFa (pg/mL) levels in the LPS Lung Model

TNFa levels in the LPS lung preclinical efficacy model

Mean group TNFa (pg/mL) levels in mice administered LPS and then treated with either vehicle or Dexamethasone. 

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  • mouse LPS Lung
  • rat LPS lung 






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