Rodent models of immune-mediated arthritis (RMIA) are commonly used to evaluate the mechanisms of inflammatory joint disease, as well as test the efficacy of anti-arthritic compounds. Collagen induced arthritis (CIA) and adjuvant induced arthritis (AIA) are two commonly used models for this purpose. At MD Biosciences we offer our clients the novel and rapid collagen antibody-induced arthritis (CAIA) model.
Our expertise includes Collagen-induced RA, Collagen antibody-induced, and Adjuvant-induced RA. See below information to learn more about our experience/readouts/options:
|Biologics||Arthritis score||Biomarkers (protein, mRNA)|
|NCEs||Paw thickness||Cell populations by FACS|
|Plant-based compounds||Body Weights||Histology/IHC|
Our scientist are ready to assist you with your preclinical Rheumatoid arthritis study. Together we can research this chronic, systemic disease that manifests itself mainly as a disabling destruction of the synovial joints of the hands and feet.
We know that Rheumatoid arthritis is a disease that's initiation results in profound changes in the structure and composition of the synovium and synovial fluid; with the infiltration of inflammatory cells, synovial cell hyperplasia, increased angiogenesis, fibroblast proliferation and extracellular matrix production. This increase in synovial cell proliferation can result in the lining increasing up to five times its original size and can result in pannus formation. The culmination of these events is bone and cartilage erosion and loss of joint function.
We also know joint destruction is induced by dysregulated immune activation of both the innate and adaptive immune responses resulting in alterations in the synovium, cartilage and bone. The normal joint has a thin synovial lining (intimal lining layer), 1-3 cells thick. Beneath this is a sub-lining layer of connective tissue scattered with immune cells, blood vessels and nerve cells. Together these layers form the synovium, which produces the synovial fluid that serves to lubricate the joint.
Our scientists are readily available to discuss your efficacy study needs of the Rheumatoid arthritis disease. Contact a scientist to discuss an efficacy study in one of our preclinical models of Rheumatoid Arthritis today.