Inflammatory Joint Disease Models
Rodent models of immune-mediated arthritis (RMIA) are commonly used to evaluate the mechanisms of inflammatory joint disease, as well as test the efficacy of anti-arthritic compounds. Collagen induced arthritis (CIA) and adjuvant induced arthritis (AIA) are two commonly used models for this purpose. At MD Biosciences we offer our clients the novel and rapid collagen antibody-induced arthritis (CAIA) model as well.
Our expertise includes Collagen-induced RA, Collagen Antibody-induced RA, and Adjuvant-induced RA. See below information to learn more about our experience/readouts/options:
|Biologics||Arthritis score||Biomarkers (protein, mRNA)|
|NCEs||Paw thickness||Cell populations by FACS|
|Plant-based compounds||Body Weights||Histology/IHC|
Our scientists stand ready to assist with your preclinical Rheumatoid Arthritis studies. Together we can research this chronic, systemic disease that manifests itself mainly as a disabling destruction of the synovial joints of the hands and feet.
In RA, joint destruction is induced by dysregulated immune activation of both the innate and adaptive immune responses, resulting in alterations in the synovium, cartilage and bone. The normal joint has a thin synovial lining (intimal lining layer), 1-3 cells thick. Beneath this is a sub-lining layer of connective tissue scattered with immune cells, blood vessels and nerve cells. Together these layers form the synovium, which produces the synovial fluid that serves to lubricate the joint.
Initiation of Rheumatoid Arthritis results in profound changes in the structure and composition of the synovium and synovial fluid, including infiltration of inflammatory cells, synovial cell hyperplasia, increased angiogenesis, fibroblastic cell proliferation and extracellular matrix production. This altered synovial environment, coupled with increased cell proliferation, often results in an increase in the thickness of the synovial lining (up to as much as 5x the thickness) and can ultimately lead to pannus formation, erosion of the bone and/or cartilage and eventual loss of joint function.
Our scientists are readily available to discuss your efficacy study needs for Rheumatic disease such as RA. Contact us today to discuss an efficacy study in one of our preclinical models of Rheumatoid Arthritis.