Evaluate the mechanisms of gastrointestinal inflammation.
An early event though to participate in the pathogenesis of IBD is the disruption of the gastrointestinal epithelial barrier. This disruption leads to the mixing of microbial pathogens from the lumen with antigen presenting cells in the lamina propria producing an inflammatory response. The resulting pro-inflammatory cytokines and chemokines recruit and activate leukocytes, regulate the integrity of the epithelial barrier and stimulate the production of chemokines from epithelial cells. Together these events lead to chronic inflammation in the intestines.
Rodent models of IBD are commonly used to evaluate the mechanisms of gastrointestinal inflammation. DSS and TNBS are two commonly used models for this purpose.
|Biologics||IBD score||Biomarkers (protein, mRNA)|
|NCEs||Colon length/weight||Cell populations by FACS|
|Plant-based compounds||Body Weight/loss||Histology/IHC|