Oxazalone-induced Delayed Type Hypersensitivity (DTH) model
Our Delayed Type Hypersensitivity (DTH) model evaluates the cell-mediated immune response to repeated exposure of skin to oxazolone. This results in a DTH reaction involving CD4+, CD8+ T cells and macrophages, resulting in local skin inflammation characterized by an increased thickness of the skin. An initial sensitization is followed by a challenge, which sets off a release of cytokines initiating a robust inflammatory response. Below are the assessment types and study data.
Circulating or tissue level Biomarker analysis (protein or mRNA)