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Preclinical Laboratory Services

Oxazalone-Induced DTH Model

Dermatological Modeling for Inflammatory and Autoimmune Diseases of the Skin

 

Oxazalone-Induced Delayed Type Hypersensitivity (DTH) Model

 Our Delayed Type Hypersensitivity (DTH) model evaluates the cell-mediated immune response to repeated exposure of skin to oxazolone. This results in a DTH reaction involving CD4+, CD8+ T cells and macrophages, resulting in local skin inflammation characterized by an increased thickness of the skin. An initial sensitization is followed by a challenge, which sets off a release of cytokines initiating a robust inflammatory response. Below are the assessment types and study data.

 

 

Assessments:

  • Ear thickness
  • Circulating or tissue level Biomarker analysis (protein or mRNA)
  • Cell Populations in Spleen/Lymph Node by FACS
  • Histology/IHC
  • PK blood collections

 

Ear Thickness in the DTH Study

ear thickness in the oxazalone-induced DTH efficacy model

Ear thickness of subjects treated with vehicle or Dexamethasone in the oxazalone-induced DTH model.

 

SPECIES AVAILABLE:

  • rat DTH
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