Dermatological Modeling for Inflammatory and Autoimmune Diseases of the Skin
Our Delayed Type Hypersensitivity (DTH) model evaluates the cell-mediated immune response to repeated exposure of skin to oxazolone. This results in a DTH reaction involving CD4+, CD8+ T cells and macrophages, resulting in local skin inflammation characterized by an increased thickness of the skin. An initial sensitization is followed by a challenge, which sets off a release of cytokines initiating a robust inflammatory response. Below are the assessment types and study data.
Ear thickness of subjects treated with vehicle or Dexamethasone in the oxazalone-induced DTH model.