pain models for neuropathic, nociceptive, inflammatory and post-operative pain

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Inflammatory Pain | Preclinical Contract Research

MD Biosciences offers several models of inflammatory and arthritic pain. Models of inflammatory pain are appropriate for evaluating the following drug classes:

  • Cannabinoid Receptor Agonists
  • FAAH Inhibition
  • apha2-adrenergic agonists
  • NSAIDs
  • opioids
  • TRPV1
  • Sodium Channel Blockers

General Inflammatory Pain Preclinical Research Models           Request Proposal
Model CFA
 Carrageenan
Strain

SD rats

 SD rats
Length 24 hours
 3 hours
Positive Control Diclofenac Diclofenac
Measurements Body weight
Clinical signs
Mechanical Allodynia
Thermal Hyperalgesia
Paw volume
 Body weight
Clinical signs
Mechanical Allodynia
Thermal Hyperalgesia
Paw volume
Add-ons Blood samples Blood samples


Arthritic Pain Preclinical Research Models                               Request Proposal
Model Adjuvant-induced Polyarthritic Pain Adjuvant-induced Monoarthritic Pain
 MIA Osteoarthritic Pain
Strain

Lewis rats

 SD rats
 Wistar Hans rats
Length 28 days
 28 days
 15-35 days
Positive Control Morphine Morphine Morphine
Diclofenac
Measurements Arthritis score
Clinical signs
Body weight
Mechanical Allodynia
Thermal Hyperalgesia 		Body weight
Clinical signs
Weight bearing
Mechanical Allodynia
Thermal Hyperalgesia
 Body weight
Clinical signs
Weight bearing
Motor function test
Add-ons Paw Volume
Histology
Cytokine Analysis
Gene Expression 		Paw Volume
Histology
Cytokine Analysis
Gene Expression		 Histology
Cytokine Analysis
Gene Expression

Interesting Fact

According to an NIH statistics survey, the four most common types of pain are low back pain (27%), severe headache or migraine pain (15%), neck pain (15%), and facial pain (4%).

Client Testimonial

“Among all the CROs that I have used over the years, including recently for inflammation, MD Biosciences has been one of the very best in terms of scientific knowledge, expertise, data quality, timelines, flexibility and personal contacts.”

O.B., Director of Preclinical Research Pharmaceutical Company