The focal cerebral ischemic model of stroke is commonly used to assess ischemic injury in the brain. Occlusion of the middle cerebral artery (MCA) leads to a reduction of cerebral blood flow in both the striatum and the cortex, but the degree largely depends on the duration and site of occlusion. It is a highly reproducible model that results in focal brain damages similar to those occuring in human stroke.
The MCAo model can be used to evaluate stroke, neurodegeneration or oxygen stress.
Ischemia models for stroke
|
| Occlusion |
Permanent or Transient |
| Study Length |
variable |
| Species |
rat |
| Readouts available |
Histology, adhesive removal test, staircase, scar photography, water maze, blood glucose levels |
Figure: Histology of the brain from permanent MCAo model
Figure: adhesive removal test in permanent MCAo model