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Preclinical Laboratory Services

Focal Cerebral Ischemia MCAo Models

Middle Cerebral Artery Occlusion 

Focal Cerebral Ischemia (MCAo) models for stroke & neuro-degeneration research

The focal cerebral ischemic model of stroke is commonly used to assess ischemic injury in the brain. Occlusion of the middle cerebral artery (MCA) leads to a reduction of cerebral blood flow in both the striatum and the cortex, but the degree largely depends on the duration and site of occlusion. It is a highly reproducible model that results in focal brain damages similar to those occurring in human stroke. One can choose a permanent occlusion which produces massive damage or transient occlusion where the artery is occluded for a period of time before reperfusion.

 

The MCAo model can be used to evaluate stroke or neurodegeneration as a result of oxygen stress.

 

Ischemic MCAo models for stroke:

Occlusion: Permanent Transient
Expected Area of Damage: Cortex Stratum/Globus Plidus, Thalamic Nucleus, Hoppocampus Mainly Cortex
Cognitive/Behavior Tests: Spatial memory, contralateral motor function and coordination (Staircase, Adhesion removal test, water maze, grip test) Contralateral motor function and coordination (Staircase, adhesion removal test, grip test)
Histology Assessment: Thionin/H&E for infarct size & assessment Thionin/H&E for infarct size & assessment

 

Don't see the model or assessment you require? Our scientists are experienced with rapidly validating models from the literature. Please speak with a scientist to discuss your requirements.

 

Coronal Sections of Rat Brain Tissue Demonstrating Infacrt Size Assesment (Thionin Staining):Thionine-Staining-Of-Coronal-Brain-Sections-MCAo-Model-Ischemic-Stroke.png

Figures A & C. Normal Rat Brain Tissue. Figures B. & D. Rat brain 72 housr post-MCAo demonstrating clear damage due to infarct in the Right hemisphere.  

 

 

SPECIES AVAILABLE:

  • Rat permanent MCAo
  • Rat transient MCAo
  • Mouse transient MCAo

 

 

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