The MCAo model can be used to evaluate stroke or neurodegeneration as a result of oxygen stress.
Ischemic MCAo models for stroke:
|Expected Area of Damage:||Cortex Stratum/Globus Plidus, Thalamic Nucleus, Hoppocampus||Mainly Cortex|
|Cognitive/Behavior Tests:||Spatial memory, contralateral motor function and coordination (Staircase, Adhesion removal test, water maze, grip test)||Contralateral motor function and coordination (Staircase, adhesion removal test, grip test)|
|Histology Assessment:||Thionin/H&E for infarct size & assessment||Thionin/H&E for infarct size & assessment|
Don't see the model or assessment you require? Our scientists are experienced with rapidly validating models from the literature. Please speak with a scientist to discuss your requirements.
Coronal Sections of Rat Brain Tissue Demonstrating Infacrt Size Assesment (Thionin Staining):
Figures A & C. Normal Rat Brain Tissue. Figures B. & D. Rat brain 72 housr post-MCAo demonstrating clear damage due to infarct in the Right hemisphere.