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Preclinical Laboratory Services

Global Ischemia 4VO Model

Neurodegeneration

Global ischemia 4VO model for stroke & neurodegeneration research

The Global Ischemia model involves permanent occlusion of vertebral arteries and transient occlusion of carotid arteries. No cerebral blood flow to any area of the brain causes injury to the hippocampus. This modelmimics cardiac arrest and coronary bypass surgery.
 
The 4VO model can be used to evaluate not only lack of blood flow to brain as found in cardiac arrest and coronary bypass surgery, but also neurodegeneration, dementia and oxygen stress.
 

Assessments:

  • Histology
  • Water maze
  • Grip Test

Don't see the model or assessment you require? Our scientists are experienced with rapidly validating models from the literature. Please speak with a scientist to discuss your requirements. 

 

 

Water maze in the 4VO model

water maze test in the global ischemic 4VO model
 

Rats were given 8 trials to find the platform in the water maze test. Sham vs vehicle and test treated groups were evaluated. The animals that received the test item were able to find the platform in the water maze test in a similar fashion to sham animals. The vehicle treated animals were unable to find the platform after 8 trials. 

 

 

SPECIES AVAILABLE:

  • Rat permanent 4VO
  • Rat transient 4VO

 

 

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