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Global ischemia 4VO model

Global ischemia 4VO model for stroke & neurodegeneration research

The Global Ischemia model involves permanent occlusion of vertebral arteries and transient occlusion of carotid arteries. No cerebral blood flow to any area of the brain causes injury to the hippocampus. This modelmimics cardiac arrest and coronary bypass surgery.
The 4VO model can be used to evaluate not only lack of blood flow to brain as found in cardiac arrest and coronary bypass surgery, but also neurodegeneration, dementia and oxygen stress.


  • Histology
  • Water maze
  • Grip Test
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  • Rat permanent 4VO
  • Rat transient 4VO


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cerebral ischemia models (MCAo and 4VO) for neuroprotective therapies


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