MBP-induced EAE results in a single relapse that is characterized mainly by hind paw paralysis. On the histology level, this model is characterized by infiltration of mononuclear cells to the cervical spinal cord and formation of foci. This EAE model is self-limiting and does not show demyelination.
| MBP-induced EAE preclinical contract research model* |
| Length |
21 days
|
| Strain |
Lewis rats
|
| Induction |
MBP emulsified with CFA. Onset of disease is between day 10-13 and animals completely recover by day 21.
|
| Positive Control |
Dexamethasone |
| Assessments |
clinical sign/score, body weight, |
| Additional Options |
Histopathology, demyelination analysis, Immunohistochemistry, cytokine analysis, gene expressio, blood counts |
*Models can be customized to sponsors criteria. Contact a scientist.
Figure: Mean clinical score
