Preclinical Research

Metabolic Disease

Diabetes/Renal/Obesity/Inflammatory Bowel Disease 

Diabetes, Obesity and Metabolic Syndrome

Metabolic syndrome is increasing in incidence and described as a combination of distrubances including glucose intolerance, central obesity, dyslipedemia and hypertension. Metabolic Diseases includes conditions such as diabetes, renal, obesity and inflammatory bowel disease. Multiple induction methods may be available for each disease. Diabetes models may be induced with streptozotocin, the use of db/db or NOD mice. Inflammatory Bowel Disease (IBD) may be induced with TNBS or DSS. 

Our laboratories are set for performing specialized studies including altered light/dark cycles, individualized sample collection for biomarker analysis as well as studying various other diseases, such as rheumatoid arthritis on the background of a metabolic disease such as obesity. Biomarker studies may include multiplexed cytokine assays, mRNA or histology and immunohistochemistry.

In addition, our expert staff have the experience and the infrastructure to study the interactions between the microbiome and metabolic diseases, adding a new, important dimension to your drug development studies.

Contact us today to discuss your objectives and how we may be able to reach them! 

Experience Models Assessments
Biologicals Obesity Feed intake
New chemical entities Diabetes Insulin resistance
Plant-based compounds Acute Kidney Injury Glucose tolerance
  IBD Histology IHC
    Multiplexed cytokines
    mRNA qPCR

 

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