Surgical Ischemia & Chemically-Induced AKI Models
Acute kidney injury (AKI) or acute renal failure (ARF) is a majory kidney disease associated with high mortality in patients. Clinically, ischemia and sepsis are the leading causes of AKI, which may result from a variety of conditions such as decreased cardiac output, renal vascular occlusion or obstruction and kidney transplantation. Diabetes patients are also at risk for renovascular disease, which is a narrowing of the arteries to the kidney.
Common models for studying AKI or ARF can be divided into ischemic-induced injury models, sepsis-induced models, drug-induced (NSAID, gentamicin, cysplatin etc) as well as others. MD Biosciences has validated ischemia-induced renal injury models (unilateral and bilateral) and has familiarity with a variety of other methods should Sponsors have interest in performing validation work on a cost-share basis.
KIM-1 levels following bilateral IR injury in the mouse. KIM-1 levels are significantly elevated at 24 and 48 hours post injury.