Acute kidney injury (AKI) or acute renal failure (ARF) is a majory kidney disease associated with high mortality in patients. Clinically, ischemia and sepsis are the leading causes of AKI, which may result from a variety of conditions such as decreased cardiac output, renal vascular occlusion or obstruction and kidney transplantation. Diabetes patients are also at risk for renovascular disease, which is a narrowing of the arteries to the kidney.
Common models for studying AKI or ARF can be divided into ischemic-induced injury models, sepsis-induced models, drug-induced (NSAID, gentamicin, cysplatin etc) as well as others. MD Biosciences offers ischemia-induced renal injury and sepsis-induced renal injury.
Histology for infarct
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