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Preclinical Research

Acute Kidney Injury/Renal Failure

Metabolic/Renovascular Disease

Acute Kidney Injury (AK) and Renovascular Disease

Acute kidney injury (AKI) or acute renal failure (ARF) is a majory kidney disease associated with high mortality in patients. Clinically, ischemia and sepsis are the leading causes of AKI, which may result from a variety of conditions such as decreased cardiac output, renal vascular occlusion or obstruction and kidney transplantation. Diabetes patients are also at risk for renovascular disease, which is a narrowing of the arteries to the kidney. 
Common models for studying AKI or ARF can be divided into ischemic-induced injury models, sepsis-induced models, drug-induced (NSAID, gentamicin, cysplatin etc) as well as others. MD Biosciences offers ischemia-induced renal injury and sepsis-induced renal injury.


  • Histology for infarct
  • Creatinine/BUN
  • Kidney biomarkers
Don't see the model or assessment you require? Our scientists are experienced with rapidly validating models from the literature. Please speak with a scientist to discuss your requirements. 




  • mouse unilateral AKI
  • mouse bilateral AKI
  • rat renal AKI
  • sepsis-induced AKI


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Download biomarkers and preclinical models for acute kidney injury (AKI) acute renal failure (AFR)



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