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Immunology/Inflammation Laboratory Services

Acute Kidney Injury & Renal Failure Models

Surgical Ischemia & Chemically-Induced AKI Models

 

Acute Kidney Injury (AK) and Renovascular Disease

Acute kidney injury (AKI) or acute renal failure (ARF) is a majory kidney disease associated with high mortality in patients. Clinically, ischemia and sepsis are the leading causes of AKI, which may result from a variety of conditions such as decreased cardiac output, renal vascular occlusion or obstruction and kidney transplantation. Diabetes patients are also at risk for renovascular disease, which is a narrowing of the arteries to the kidney. 
  
Common models for studying AKI or ARF can be divided into ischemic-induced injury models, sepsis-induced models, drug-induced (NSAID, gentamicin, cysplatin etc) as well as others. MD Biosciences has validated ischemia-induced renal injury models (unilateral and bilateral) and has familiarity with a variety of other methods should Sponsors have interest in performing validation work on a cost-share basis. 

Assessments:

  • Histology for infarct
  • Creatinine/BUN
  • Kidney biomarkers
Don't see the model or assessment you require? Our scientists are experienced with rapidly validating models from the literature. Please speak with a scientist to discuss your requirements. 

 

KIM-1 levels in the bilateral AKI model

 
KIM-1 levels in the bilateral acute kidney injury model

KIM-1 levels following bilateral IR injury in the mouse. KIM-1 levels are significantly elevated at 24 and 48 hours post injury.

 MODELS AVAILABLE:

  • Mouse unilateral AKI
  • Mouse bilateral AKI
  • Rat unilateral AKI
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