MD Biosciences performs efficacy studies for proof-of-concept as well as assays for early screening and profiling of drug candidates. If there is a model or assay that you don't see listed, please contact a representative to discuss a custom assay design.
MBP-induced EAE
The Myelin Basic Protein (MBP)-induced EAE model is a self-limiting model run in the rat, completed in 21 days.
MOG-induced EAE
The Myelin Oligodendrocyte Glycoprotein (MOG) induced EAE model is a chronic progressive model in the mouse that is completed in 35 days.
Relapsing PLP-induced EAE
This model is appropriate for evaluating the effects of a compound on the relapsing-remitting disease course.
EAE Transfer Model
Under Development
Multiple Sclerosis
Multiple sclerosis is a demyelinating disease of the CNS. Although no animal model thus far establish all facets of the human MS, EAE induced in rodents represents the disease model most studied for the disease. Multiple sclerosis is one of the most common disabling neurological
diseases in young adults. The main features of the disease are focal areas of demyelination and inflammation. The pathogenesis of the disease is unclear. The disease course is unpredictable and life-long. The disease affects women more commonly for unknown reasons. The etiology of the disease seems to be dependent on genetic and environmental factors. Several studies have suggested viral infections as a contributor to the disease. EAE is mediated by autoimmune CD4+
T-Cells. These cells develop in the peripheral lymphoid organs and travel to the CNS causing an autoimmune response. The development of T cells is controlled largely by the expression of various cytokines as well as cellular adhesion molecules. The origin of the model is traced
to the development of the rabies vaccine. Encephalomyopathy was caused in a small percentage of humans who received the rabies vaccine. Subsequent studies succeeded in inducing the paralytic disease in different animals including rabbits. Finally methods were developed to cause inflammatory reaction as well as demyelination with limited number of injections. The EAE model today is the most thoroughly studied animal model for human autoimmune diseases.