The 6OHDA (6-hydroxydopamine) induced model is a unilateral lesion model of which the Nigro-Striatial pathway is damaged. Unilateral dopamine (DA) denervation induces a number of behavorial deficits similar to those observed in patients with PD. A variety of tests are used to evaluate spontaneous and drug induced behavorial changes.
| 6OHDA-induced PD preclinical contract research model* |
| Length |
15 days |
| Induction |
6OHDA is injected into the right Nigro-Striatal pathway |
| Assessments |
Apomorphine-induced rotation |
| Additional Options |
open-field test, rotarod, staircase, histology, gene expression |
*Models can be customized to sponsors criteria. Contact a scientist.
Figure 1: The number of rotations in 30 minutes after an apomorphine dose
