Using the MOG (myelin oligodendrocyte glycoprotein) to induce disaese results in an encephalitogenic T-cell response and a demyelinating auto-antibody response. MOG 35-55 peptide together with pertussis toxin (PT) will result in a chronic-progressive form of EAE in the C57BL/6. In addition to paralysis, this model is characterized with deyelination both of the spinal cord and the brain.
| MOG-induced EAE preclinical contract research model* |
| Length |
35 days |
| Induction |
MOG 35-55 peptide plus PT. Onset of disease occurs between days 10-12 |
| Positive Control |
Dexamethasone |
| Assessments |
clinical sign/score, body weight, |
| Additional Options |
Rotarod, histopathology, demyelination analysis, Immunohistochemistry, cytokine analysis, gene expression |
*Models can be customized to sponsors criteria. Contact a scientist.
Figures: Correlation between rotarod (used to evaluate cognitive function) and clinical scores in MOG-induced EAE. RPM = rotations/minute.
