MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropryidine) is an effective dopaminergic neurotoxin that selectively destroys dopamine neurons in the substantia nigra, resulting in a Parkinson's-like syndrome. This model is an acute histology based model mimicking a depletion of 50-60% in Tyrosine-hydroxilase (TH) immunoreactive cells at the level of the Substantia Nigra pars compacta (SNpc) without affecting the general motor activity. The effect is less pronounced in the nucleus accumbance, olfactory tubercle and ventral tegmental.
| MPTP-induced PD preclinical contract research model* |
| Length |
7 days |
| Induction |
Four intraperitoneal (IP) injections of MPTP are given in two hour intervals. |
| Assessments |
The acute MPTP model is based off histological analysis and TH immunoreactive analysis. |
| Additional Options |
Gene expression |
*Models can be customized to sponsors criteria. Contact a scientist.
Figure 1: Total count of TH immunoreactive IR cells.
Figure 2: Substantia Nigra pars compacta (SNpc) of naive (left) and MPTP-induced PD sample (right).
