Preclinical efficacy testing in a model of Gliosis

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LPS-induced Glial Cell Activation

Gliosis

Gliosis is a proliferation of astrocytes in the central nervous system (CNS) in response to injury which results in scar formation. Astrocytes react to injury by hypertrophy and up-regulation of the glial-fibrillary acidic protein. Gliosis, along with neuronal loss, is a prominent feature of many diseases of the central nervous system, including Alzheimer's Disease, Multiple Sclerosis, and stroke.

Interesting Fact

Multiple Sclerosis is a lifelong ailment that affects more than 400,000 Americans, resulting in an earning loss of about $10.6 billion annually for U.S. families with MS.

Client Testimonial

“Among all the CROs that I have used over the years, including recently for inflammation, MD Biosciences has been one of the very best in terms of scientific knowledge, expertise, data quality, timelines, flexibility and personal contacts.”

O.B., Director of Preclinical Research Pharmaceutical Company