Our Model Assessments Include:
Brain tissue - H&E staining
We also offer H&E staining of brain tissue for detection of inflammatory cells infiltrating into the spinal cord.
H&E Staining of Brain Tissue from MBP-Induced EAE Model
Figure A. Low magnification and Figure B. High magnification of transverse sections of brain tissue demonstrating severe infiltration of inflammatory cells into the white matter.
H&E Staining of Transverse Section of the Spinal Cord from MBP-Induced EAE Model in Rats
(A-D, Vehicle Group, Inflammed Spinal Cord Tissue): Figure A. Low magnification of infammatory infiltrate in the white matter of the spinal cord. Figure B. Medium magnification of foci of inflammatory infiltrate. Figure C. High magnification shows mixed populations of mononuclear cells (black arrows). Figure D. Medium magnification of foci of inflammatory cells (black arrowheads).
E-G (Dexamethasone Group, normal appearance of the spinal cord): Figure E. Low magnification of the spinal cord showing minimal inflammatory infiltrate. Figure F. Medium magnification of a minimal foci of inflammatory infiltratate (circled). Figure G. High magnification of circled area in F showing several mononuclear cells (black arrows) surrounded by 2 blood vessels (asterisks) at the junction of the gray and white matter (black lines).
Our scientists are highly experienced with MS models. Contact a scientist to discuss your study requirements today!