pain models for neuropathic, nociceptive, inflammatory and post-operative pain

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Neuropathic Pain | Preclinical Contract Research

Neuropathic Pain is produced by damage to the neurons in the peripheral and central nervous systems and involves sensitization of these systems. In peripheral sensitization, there is an increase in the stimulation of peripheral nociceptors that amplifies pain signals to the central nervous system (CNS). In central sensitization, neurons that originate in the dorsal horn of the spinal cord become hyperstimulated, increasing pain signals to the brain and thereby increasing pain sensation. It is most commonly associated with chronic allodynia and hyperalgesia.

MD Biosciences offers a wide range of pre-clinical contract research models for neuropathic pain that can be customized according to sponsors criteria. Models of Neuropathic pain are appropriate for evaluating the following drug classes:

  • Cannabinoid Receptor Agonists
  • FAAH Inhibition
  • apha2-adrenergic agonists
  • tricylic anti-depressants
  • opioids
  • TRPV1
  • Sodium and calcium Channel Blockers

Neuropathic Pain Preclinical Research Models                 Request Proposal
Model CCI Chronic Constriction Injury (Bennett & Xie)* Spinal Nerve Ligation (Chung)* Taxol STZ Diabetic Neuropathy
Strain

SD rats

 SD rats SD rats Hans Wistar rats
Length 14 days 14-28 days 15 days 20 days
Positive Control Morphine
Gabapentin		 Morphine
Gabapentin		 Morphine Morphine
Gabapentin
Measurements Body weight
Clinical signs
Mechanical Allodynia		 Body weight
Clinical signs
Mechanical Allodynia

Body weight
Clinical signs
Mechanical Allodynia
Thermal Hyperalgesia

 Blood Glucose
Body weight
Clinical signs
Mechanical Allodynia
Add-ons Blood samples, histology Blood samples, histology Blood samples Blood samples, histology

*Whitepaper: Peripheral Nerve Injury Models of Neuropathic Pain. Understanding the mechanisms underlying Neuropathic pain syndroms is crucial to the development of more effective therapies. 

Interesting Fact

According to an NIH statistics survey, the four most common types of pain are low back pain (27%), severe headache or migraine pain (15%), neck pain (15%), and facial pain (4%).

Client Testimonial

“Among all the CROs that I have used over the years, including recently for inflammation, MD Biosciences has been one of the very best in terms of scientific knowledge, expertise, data quality, timelines, flexibility and personal contacts.”

O.B., Director of Preclinical Research Pharmaceutical Company