<img height="1" width="1" style="display:none;" alt="" src="https://dc.ads.linkedin.com/collect/?pid=217082&amp;fmt=gif">

MD Biosciences Blog

Now Offering Synaptic Imaging Assay For Cognition and Neurodegenerative Disease Research

Posted by MD Biosciences on Mar 5, 2019 10:18:22 AM

 A powerful method for cognition, learning and degenerative disease research

 

MD Biosciences offers a synaptic imaging assay for evaluating the effect of different treatments on synapse formation and identification. This assay allows the estimation of inhibitory/excitatory synapses ratio and synaptic strength, a powerful method advancing cognition, learning and degenerative disease research and treatment options. 

Screenshot 2019-03-05 10.13.19

Unique Readouts:

  • Synaptic Count
  • Synaptic Strength
  • Identification of synapse type (excitatory/inhibitory)

 

Call or contact us today for more information!

Contact Us!

 

Read More

Topics: Neuro/CNS, assays, Neuroscience, Nerve Injury, cognition research

Senerga Cell-based Assay for Nerve Injury

Posted by MD Biosciences on Feb 19, 2019 10:26:36 AM

 A novel, rapid in-vitro assay for the screening of compound effects                                                              in nerve injury

Neurite outgrowth is the projection and extension of axonal processes from neuronal cell bodies. Through this process, neurons organize themselves into highly-complex functional networks connected synaptically to one another.


Modulation of this neurite outgrowth process (neuritogenesis) has been implicated in a wide range of CNS diseases, including neurodegenerative disorders such as spinal cord injuries, Parkinson’s Disease and Stroke.

 

MD Biosciences has developed a cell-based platform using primary cells extracted from adult rat, to evaluate the effect of tested compounds in the presence of inhibitory factors. The assay’s unique characteristics enable yielding more translatable results, which can serve as a predictive tool of the compounds’ efficacy in older animals and eventually in humans.

MD Biosciences offers an in-vitro assay to evaluate the effect of potential therapeutics on neurite outgrowth and connectivity (synaptic formation) in primary neuronal cell culture. 

image001


                                                                                     Neurite outgrowth after spinal cord injury in adult animal (Day 7)
Unique Screen Characteristics:

  1. Assays on spinal cord and cortex cell culture
  2. Primary neuronal cells extracted from adult animals
  3. Fast turnaround with results available in approximately 7 days
  4. Primary readout:  number of developed cells and the length of neurites in the presence of the tested compound and vehicle

Call or contact us today for our special introductory price of $1900 per compound. 

Contact Us!

 

Read More

Topics: Neuro/CNS, assays, Neuroscience, Nerve Injury

MD Biosciences GLP-approved Histopathology Laboratory launches new website: featuring histology, IHC, ISH and digital pathology services

Posted by MD Biosciences on Feb 15, 2019 8:00:00 AM

Our new histopathology website is now live! Check it out here!

MD Biosciences Laboratories offer a broad range of histology, immunohistochemistry (IHC) and In-situ hybridization services, staining services, tissue processing and digital pathology to enhance readouts and study applicability to the clinic.

We operate two distinct histology and IHC laboratories, including a GLP developmental research laboratory and a CLIA clinical IHC laboratory, offering a broad range of state-of-the-art technical capabilities to meet research and clinical study needs. Method development and optimization in addition to routine analysis shapes the foundation for our tissue-based services. The laboratories are equipped with advanced automated staining systems and digitized imaging, facilitating the privileged access to large, annotated image files. Services are complimented by the Visiopharm artificial intelligence-based image analysis platform to enhance the quality and speed of analysis. Services are supported by expert consultant pathologists specialized in various areas. 

Contact us to learn more about our services!

Contact Us!

Read More

Topics: CRO/outsourcing, Pathology, GLP Histopathology, Histology, GLP, Artificial Intelligence, In-situ Hybridization, CLIA certified, Immunohistochemistry, Tissue Processing

MD Biosciences Recognized As a Top 10 CRO by PharmaTec

Posted by MD Biosciences on Dec 13, 2018 10:42:24 AM

MD Biosciences was recently recognized by PharmaTec as a 'Top 10 most innovative CRO companies' for the European Market.

To learn more about recent technology advancements or have specific study inquiries, please contact us as we we would be happy to discuss with you. 

#biotechnology #innovation #CRO

Read More

New MDB Publication: Pig open field data in the PNT model for neuropathic pain

Posted by MD Biosciences on Oct 12, 2018 10:00:00 AM

We recently published a publication demonstrating the utility of open field testing in combination with behavioral scoring in the pig peripheral neuritis trauma (PNT) model for pain. Combined together and applied in this model, they represent a powerful tool to assess the spontaneous behavior of pigs in response to pain. Rodent models are often used in pain research as they offer valuable data regarding underlying mechanisms contributing to pain, though they are limited in their translatability to human application. A pivotal benefit of using pig models is their increased translatability to the clinic considering the anatomical and physiological similarities pigs share with humans in comparison to rodents. This paper suggests that pig behavioral patterns are similarly translatable. MD Biosciences is proud to be a leader in neurology-related research, offering a variety of pig studies to enhance development in multiple therapeutic areas.
 

 For more information regarding our pig study services, visit our website or contact us!

 

Read More

Topics: Pain, Stress, trauma pain, pain biomarkers, CNS imaging, Academic Researh, preclinical research, translational research, Behavioral Research, porcine model

Porcine incisional pain model pioneered by MDB scientists referenced in medical research journal

Posted by MD Biosciences on Jul 25, 2018 10:35:15 AM

MD Biosciences recognized in a paper published by Medtronic, a medical research company, to examine the efficacy of a sustained-release clonidine depot, placed in the wound bed, in a pig incisional pain model. To read the full paper, visit Dove Press Journal of Pain Research.

In addition to incisional pain models, other wound healing models offered at MD Biosciences are excisional woundings, heat wounds/burns, UV wounds and post-operative pain wounds. Contact us to discuss study-specific inquiries!

 

preclinical models of wound healing: full-thickness incisional and excisional 

 




Read More

Pig post operative pain model pioneered by our scientists recognized in a scientific publication: Synergistic Effect of Bupivacaine and Meloxicam in Clinical & Animal Studies

Posted by MD Biosciences on Jul 12, 2018 10:45:29 AM

Proud to announce that the pig post operative pain model pioneered by our scientists was used and cited in a clinical study poster publication written by Heron Therapeutics to assess the synergistic effect of Bupivacaine and Meloxicam in HTX-011.

"Meloxicam and Bupivacaine combined in a single extended-release formulation (HTX-011) delivered at the wound site in a preclinical post-surgical pain model in pigs exhibited greater analgesia than either compound delivered alone within the same extended-release formulation; this finding was confirmed in an initial clinical trial in bunionectomy" (Heron Therapeutics, 2018).

To learn more about our rodent and pig post-operative pain models, visit our preclinical pain webpage or view  our datasheet below.

pig post-operative pain (POP) model, preclinical efficacy 

Read More

Topics: Pain, post-operative pain, neuropathic pain, preclinical research

Now Available: Electrophysiology Laboratory Services featuring DANTEC Keypoint Focus

Posted by MD Biosciences on Jul 12, 2018 10:00:00 AM

 MB Biosciences is proud to announce our newly established electrophysiology capabilities suited for preclinical neuropathy research! Our lab has acquired the cutting-edge Dantec KEYPOINT Focus tool utilized to measure electrophysiological action potentials. Our scientists have applied these new capabilities in the assessment of Muscle Action Potential (measuring signals from the nerve to muscle) in rodent models of peripheral nerve injury. Using these capabilities, we can measure nerve regeneration, degeneration and protection in response to various treatments. This technology can be further applied to non-rodent species such are our pig translational pain models. Additionally, we are now offering measurement capabilities for Motor Action Potential with a specialized Renovo Neural paradigm—particularly useful for studies of EAE, MS, spinal cord injuries and CNS pain. Application of these capabilities specifically to EAE and MS models provide valuable insights into multiple areas of compound efficacy. View the graphs below to learn more about the ways in which using intraoperative techniques applied in the brain, peripheral nerve surgeries and spine has led us to developing models for monitoring impairment in neural activity. By empirically evaluating neural diseases and their physiological symptoms, we can effectively offer precise measurements for drug effect and treatment options.


To learn more about how this technology can be applied to specific study needs, please contact us.

 

In-vivo neurophysiology

 

A                                             B                                                  C

PIC1-1PIC22-1PIC33-1

Figure 1. A) CNS model - Transcranial electric motor evoked potentials (tcMEPs) were recorded from the bilateral tibialis anterior (TA) muscles using paired subdermal needle electrodes. TcMEP stimulating electrodes were placed anterior to the C3 and C4 scalp positions. B) Pain and sensory model - Somatosensory evoked potential (SSEP) - electrodes were placed along the medial aspect of each ankle at the malleoli for bipolar stimulation of the posterior tibial nerves (PTN). Somatosensory evoked potentials (SSEP) were recorded over the cerebral cortex using subdermal needle electrodes placed posterior to the C3 and C4 scalp positions. Recording electrodes were referenced to the FPz position on forehead. C) PNS model - Compound muscle action potential (CMAP) - recorded from the tibialis anterior muscle using paired subdermal needle electrodes. Stimulating electrodes were placed along the sciatic notch. Data were recorded from a Sprague Dawley rat.

   A                                              B                                            C                                               

PIC4-1PIC5-1Picture3

 

Figure 2: tcMEP Recordings from TA muscle in a multiple sclerosis model. A A healthy potential recorded from naive mouse (C57). B) Desynchronized potential recorded from a mouse treated with MOG demonstrating a clinical paralysis score of 1-2 (mild paralysis). Note multiple picks of potential, late latency for the main potential and extended duration of the total event. C) Small and weak potential recorded from a mouse treated with MOG demonstrating a clinical paralysis score of 3-4 (moderate paralysis).

Read More

Topics: Pain, neuropathic pain, preclinical research, Electrophysiology

Expanding Our Selection of Cutting-Edge CLIA and GLP Capabilities: BD LSR Fortessa™ Flow Cytometer

Posted by MD Biosciences on Jun 22, 2018 10:03:31 AM

MD Biosciences is proud to announce a recent addition to our extensive laboratory services and capabilities: The BD LSR FortessaTM X-20 Flow Cytometer offers the flexibility to support multiparametric (16+ color) analyses with advanced performance and consistency. These capabilities provide increased functionality for applications in preclinical, translational and clinical programs such as immunophenotyping of complex cellular populations, and analysis of cellular activation and proliferation states. Contact us to learn about our flow cytometry capabilities or discuss a study proposal with our scientific team! 

44
Read More

Topics: clinical research, preclinical research, translational research, Biotechnology, immunophenotyping, flow cytometry

MDB Receives 2018 Progress MN Award For Industrial & Economic Development In The Pharma & Biotech Sector Through US Minnesota-Based Site

Posted by MD Biosciences on Apr 6, 2018 10:57:40 AM

Oakdale, Minnesota USA

Nominated via the Minnesota State Dept. Of Employment and Economic Development (DEED), the Progress MN award, offered by Finance & Commerce, recognizes innovative companies that have provided major contributions to business, industrial growth and economic development in innovative and unique ways.

4FrontComplex

MD Biosciences US-site at the 4Front Technology & Office Campus in Oakdale, MN.

 

Taken from Finance and Commerce Website:

https://finance-commerce.com/2018/04/progress-mn-md-biosciences-inc/

 April 6, 2018

 

Eddie Moradian, CEO of the family-owned MD Biosciences Inc., moved to Minnesota in 2008 from Switzerland to take over the company’s American operations.

Headquartered in Switzerland, MD Biosciences operates facilities and laboratories in that country, Israel and Minnesota.

The Minnesota location provides MD Biosciences with a central location and a highly dedicated and educated pool of researchers, health care centers and universities.

The company operates early-stage drug discovery and development laboratories in Minnesota. Labs at the two other locations often participate together in collaborative or fee-for-service pharmaceutical projects, Moradian said.

On a second front, MD Biosciences works closely with pharmaceutical and clinical laboratories in developing advanced clinical diagnostic tools and research products for inflammation, neuro-inflammation, immunological and oncological disease areas.

MD Biosciences has an in-depth expertise and scientific platform that attracts “novel” drug development work in the neurological, inflammatory and oncological disease areas, he said.

Such collaborations, along with internal developments, have resulted in a pipeline of non-opioid compounds for neuropathic pain, an advanced cancer program and blood-based diagnostic tool for a specific cancer, currently in clinical trials.

In 2016, Moradian partnered with Slumberland in the creation of an advanced, multi-technological incubator in Oakdale. “Incubology” offers dry and wet laboratory space, clean rooms and office space to companies in various areas, include biomolecule production, diagnostic processes, medical devices, nanotechnology and chemical synthesis.

“We believe that Incubology will soon grow to be an important regional anchor and seeding ground for new companies and technologies,” he said, “We are truly excited about what the future may bring.”

 

 

About MD Biosciences:

MD Biosciences is a leading provider of preclinical, translational and clinical-phase contract research services.  Established in 1991, MDB provides expertise and services in areas including cancer, cardiovascular, metabolic, inflammatory and neurological conditions including pain-associated disease as well as surgical procedures. Through collaborations with pharmaceutical and medical device pioneers, MDB develops innovative therapeutics and diagnostic assays. Each scientist at MDB is highly specialized, and has an in-depth understanding of a variety of disease mechanisms and how to modulate them. This expertise, strengthened with over 10 years of pharmaceutical efficacy experience, brings value to drug development programs whether the focus is on new therapies or repositioning approved, expiring or failed therapies. Furthermore, MDB's clinical services operate at state of the art laboratories staffed with highly experienced scientists and technicians utilizing the newest and most advanced equipment available. All clinical work is performed according to CLIA standards, and may include assay development and validation, protocol design, sample archiving, and biomarker analysis services.

 

About Incubology:

Incubology was founded to bring technology start-ups together in a shared environment. Members have the benefit of dedicated lab and office space in close proximity to other entrepreneurs from diverse disciplines including biotech, pharma, device, nano and chem. With innovative thinkers from a variety of tech industries in one setting, the opportunity for shared business resources and services is a definite advantage over single-unit space. And as part of a growth-oriented campus, the possibilities for the future are endless.

www.incubology.com

 

About Finance and Commerce:

Finance and Commerce is the only daily newspaper devoted exclusively to business in the Twin Cities (MinneapolisSaint Paul) of Minnesota. Founded in 1887, it provides extensive coverage of Twin Cities business news in the areas of real estate, construction, technology, banking, energy, health care and advertising. It is the official newspaper for Hennepin County and the City of Minneapolis.

https://finance-commerce.com

 

For more information, please contact MD Biosciences at: info-us@mdbiosciences.com 

Read More

Topics: Biomarkers, drug development, clinical research, clinical diagnostics, preclinical research, translational research