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High ArthritoMabTM Antibody Cocktail Activity |18-day RA Model Balb/c Mice

Posted by Amy Clausen on Apr 3, 2007 11:33:00 AM

MD Biosciences releases histology results from an 18-day model of arthritis induced using the ArthritoMab(TM) cocktail of arthritogenic antibodies in Balb/c mice. Results show significant histological changes in the joint of the arthritis group as compared to the normal control group after just 18 days, providing researchers valuable data quickly compared to the traditional collagen-induced arthritis (CIA) model, which can take several weeks or more to produce similar histological results.

Results show significant histological changes in the joint of the arthritis group as compared to the normal control group after just 18 days, providing researchers valuable data quickly compared to the traditional collagen-induced arthritis (CIA) model, which can take several weeks or more to produce similar histological results. Figures 1-3 show the effectiveness of the arthritogenic antibodies, with mean histology scores and staining sections indicating the degree of erosion, hyperplasia and infiltration in the joint of the arthritis group as compared to the control group.

 

ArthritoMab histology

 

 

The ArthritoMabTM Arthritogenic Antibody Cocktail is comprised of 4 monoclonal antibodies to collagen type II (CII) that have been chosen for their epitope specificity. An antibody response to certain epitopes is better associated with arthritis than a response to other epitopes. In the CIA model, the antibody response correlated with arthritis was mainly associated with binding to the epitopes C1, J1, and U1. The ArthritoMabTM monoclonal antibodies were selected to bind to the epitopes C1, J1, U1 and D3 - which are spread over the entire CII region (fragments CB8, CB10 and CB11) encouraging better immune complex formation on the cartilage surface for the initiation of arthritis. The antibody-induced arthritis model using the ArthritoMabTM Arthritogenic Antibody cocktail is a rapid alternative the CIA model.

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MD Biosciences provides products and pre-clinical services for companies engaged in inflammations and neurology research. The company is headquartered in Switzerland under Morwell Diagnostics and has specialized laboratories located in Minnesota, Glasgow, and Israel. A panel of scientific experts provides companies’ in-depth expertise and technologies to tackle problems and provide flexible drug discovery solutions, enabling smarter results faster.

 

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Topics: Inflammation, Research Products