MD Biosciences Blog

 A novel, rapid in-vitro assay for the screening of compound effects                                                              in nerve injury

Neurite outgrowth is the projection and extension of axonal processes from neuronal cell bodies. Through this process, neurons organize themselves into highly-complex functional networks connected synaptically to one another.

Modulation of this neurite outgrowth process (neuritogenesis) has been implicated in a wide range of CNS diseases, including neurodegenerative disorders such as spinal cord injuries, Parkinson’s Disease and Stroke.

MD Biosciences has developed a cell-based platform using primary cells extracted from adult rat, to evaluate the effect of tested compounds in the presence of inhibitory factors. The assay’s unique characteristics enable yielding more translatable results, which can serve as a predictive tool of the compounds’ efficacy in older animals and eventually in humans.

MD Biosciences offers an in-vitro assay to evaluate the effect of potential therapeutics on neurite outgrowth and connectivity (synaptic formation) in primary neuronal cell culture. 

                                                                                     Neurite outgrowth after spinal cord injury in adult animal (Day 7)
Unique Screen Characteristics:

1. Assays on spinal cord and cortex cell culture
2. Primary neuronal cells extracted from adult animals
3. Fast turnaround with results available in approximately 7 days
4. Primary readout:  number of developed cells and the length of neurites in the presence of the tested compound and vehicle

Call or contact us today for our special introductory price of $1900 per compound. 

Our new histopathology website is now live! Check it out here!

MD Biosciences Laboratories offer a broad range of histology, immunohistochemistry (IHC) and In-situ hybridization services, staining services, tissue processing and digital pathology to enhance readouts and study applicability to the clinic.

We operate two distinct histology and IHC laboratories, including a GLP developmental research laboratory and a CLIA clinical IHC laboratory, offering a broad range of state-of-the-art technical capabilities to meet research and clinical study needs. Method development and optimization in addition to routine analysis shapes the foundation for our tissue-based services. The laboratories are equipped with advanced automated staining systems and digitized imaging, facilitating the privileged access to large, annotated image files. Services are complimented by the Visiopharm artificial intelligence-based image analysis platform to enhance the quality and speed of analysis. Services are supported by expert consultant pathologists specialized in various areas. 

Contact us to learn more about our services!