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Lumican & Keratocan Monoclonal Antibodies | Eye/Cornea

Posted by MD Biosciences on Dec 9, 2008 11:12:00 AM


St Paul, MN, December 9, 2008 – MD Biosciences, a global biotechnology company focused in inflammations and neurology research, announces the launch of Lumican and Keratocan Monoclonal Antibodies. Both Lumican and Keratocan play a role in the development and maintenance of corneal transparency making them ideal for applications in Eye and Cornea Research.

 

Lumican and Keratocan belong to the Small Leucine Rich Proteoglycan (SLRP) family. Keratocan was originally found to be a cornea specific keratan sulphate proteoglycan. Lumican is a proteoglycan expressed in extracellular matrix (ECM) and connective tissues where it has been reported to contribute to collagen fibrillogenesis, tissue hydration, migration and proliferation. Lumican modified with keratan sulphate, constitutes one of the major proteoglycans of the corneal stroma, where it stimulates cell migration on the corneal epithelium and is also believed to play a regulatory role for keratocan. Mutations of keratocan cause cornea plana in humans, which is often associated with glaucoma, whereas the absence of Lumican leads to formation of cloudy corneas. This suggests that Keratocan and Lumican have different roles in regulating the formation of stromal extracellular matrix.

 

Both the Lumican Monoclonal Antibody (Catalog 1042007) and the Keratocan Monoclonal Antibody (Catalog 1042008) are IgM antibodies that are affinity purified on a thiophilic column. The Lumican antibody recognizes a protein epitope and is specific for human, bovine, mouse and porcine tissues. The keratocan antibody recognizes a protein core epitope and is specific for human, bovine, porcine, mouse and chicken tissues. Both antibodies are supplied as liquid, ready to use, at a concentration of 0.1 mg/mL for ELISA, Western Blot and IHC applications.

 

In addition to Lumican and Keratocan antibodies, MD Biosciences also supplies a line of Aggrecan, Collagen, MMP, Proteoglycan, Protease, and T cell specific reagents that encompass natural and recombinant proteins, antibodies, ELISAs and assays. For additional information on any of the reagents or services provided, please visit the website at www.mdbiosciences.com.

 

About MD Biosciences

MD Biosciences provides products and pre-clinical services for companies engaged in inflammations and neurology research. The company is headquartered in Switzerland under Morwell Diagnostics and has specialized laboratories located in Minnesota, Glasgow, and Israel. A panel of scientific experts provides companies’ in-depth expertise and technologies to tackle problems and provide flexible drug discovery solutions, enabling smarter results faster.

 

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The information in this press release should be considered accurate only as of the date of the release. MD Biosciences has no intention of updating and specifically disclaims any duty to update the information in these press releases.

 

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Topics: eye, cornea

MD Biosciences Showcases its Products & Services at APLAR Conference.

Posted by MD Biosciences on Sep 22, 2008 11:18:00 AM


St Paul, Minnesota, September 22, 2008 – MD Biosciences, a global biotechnology company focused in inflammations & neurology research will showcase its inflammations related pre-clinical services and research products at the 13th Congress of The Asia Pacific League of Associations for Rheumatology (APLAR) in Japan on September 23 – 27, 2008. APLAR focuses on providing state of the art care to patients with arthritis and other musculoskeletal diseases through continuing professional development of members, increasing the awareness and understanding about rheumatic diseases, patient advocacy and empowerment, and fostering research in the field of rheumatic diseases.

MD Biosciences, with roots in the sales of rheumatoid arthritis research reagents, will feature it’s capabilities in preclinical outsourcing services such as the Collagen-Induced Arthritis (CIA), Collagen Antibody-induced Arthritis (CAIA), Adjuvant Induced arthritis (AIA), Monoarthritic Pain, along with general inflammation assays and the Senerga® Mode of Action Platform. MD Biosciences offers customization of all protocols as well as end-point readouts such as biomarker analysis, histology, and gene expression analysis. MD Biosciences research products featured at the conference include collagen related reagents and assays, ArthritoMab™ antibody cocktail, ELISAs, Aggrecan antibodies and T-cell antibodies.

In addition to the product and service offerings within Arthritis, MD Biosciences also offers products and services within other therapeutic areas such as Multiple sclerosis, Respiratory, IBD, Type I Diabetes, Endotoxic shock, Contact Dermatitis, Inflammatory and Arthritic Pain, Gliosis, and Parkinson's Disease.

Our Inflammations Discovery Service offers quick start dates and timely delivery of data, specialized scientists with experience using small molecules and biologicals, standard and specialized routes of administration, customized protocols and the development of novel models.

About MD Biosciences
MD Biosciences provides products and pre-clinical services for companies engaged in inflammations and neurology research. The company is headquartered in Switzerland and has specialized laboratories located in the United States, United Kingdom, and Israel. A panel of scientific experts provides companies’ in-depth expertise and technologies to tackle problems and provide flexible drug discovery solutions, enabling smarter results faster.

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The information in this press release should be considered accurate only as of the date of the release. MD Biosciences has no intention of updating and specifically disclaims any duty to update the information in these press releases.


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MD Biosciences Offers Monoarthritic Pain Model

Posted by MD Biosciences on Sep 10, 2008 11:23:00 AM


MD Biosciences, a global biotechnology company focused in inflammations and neurology research, is expanding its line of arthritis and pain preclinical services with the addition of the CFA-induced monoarthritic pain model. The model offers advantages over traditional arthritis models in that disease develops in only one joint allowing a comparison to the healthy joint. The quantification of pain associated with arthritis can be useful in elucidating the mechanisms of arthritis as well as evaluating the efficacy of anti-arthritic drug compounds in the discovery phase.

The monoarthritic pain model is a 28-day model with arthritis and subsequent pain present in a single joint. Pain response develops 1 day post-induction. Readouts available are clinical signs and scoring, body weights, mechanical and thermal stimuli, weight bearing, histology and cytokine analysis.

Monoarthritic Pain

In addition to the monoarthritic pain model, MD Biosciences offers the traditional Adjuvant-induced arthritis model that allows for traditional pain measurements as well as a record of spontaneous pain using the Foot Print of Pain method. Other Arthritis models and research reagents include the Collagen Induced Arthritis (CIA) and Collagen Antibody Induced Arthritis (CAIA), ArthritoMab™ Arthritogenic Antibody Cocktail, Collagen Reagents, Collagen Antibodies and Collagen-related ELISA Kits and Assays.

About MD Biosciences
MD Biosciences provides products and pre-clinical services for companies engaged in inflammations and neurology research. The company is headquartered in Switzerland and has specialized laboratories located in the United States, United Kingdom, and Israel. A panel of scientific experts provides companies’ in-depth expertise and technologies to tackle problems and provide flexible drug discovery solutions, enabling smarter results faster.

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The information in this press release should be considered accurate only as of the date of the release. MD Biosciences has no intention of updating and specifically disclaims any duty to update the information in these press releases.

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Topics: Pain, Inflammation, Arthritis