Syngenic tumor models are excellent preclinical models for studying the interaction of tumor cells with the host immune system as well as the impact of tumors on local and systemic factors such as the surrounding tissue and the vascular system. They utilize injected tumor cells or tissue from the same species and genetic background as the host, which permits the assessment of compatible tumor-stroma microenvironmental interactions, endocrine signaling and immune responses. Unlike xenotransplantation models where the hosts are immunocompromised to enable the innoculation of human tumors or cells into murine hosts without rejection, syngenic tumor models utilize immuocompetent hosts allowing immune-cell-tumor-cell interactions. This is critical as a functioning immune system is the backbone of studies involving cytotoxic T cells, Tregs, tumor-associated macrophages, cell trafficking or inflammatory fibrotic stromal reactions. Additionally, the effects of an intact immune system on the onset of metastasis and progression are important.
Orthotopic Tumor models are created on the basis of injecting tumor cells directly into the organ of origin and exhibit organotypical interactions between the tumor cells and the surrounding stroma. These interactions affect the growth, differentiation and drug sensitivity of the tumor cells.
Metastasis Models are created on the basis of injecting tumor cells directly to the systemic circulation. The site of injection will largely dictate which metastasis will develop as the cells will arrest in the first capillary bed encountered.
MD Biosciences research group is actively involved in developing approaches, methods and models that bring greater translational relevance to the clinical situation. With a high failure rate in the clinical trial phase of drug development, more relevant models are needed that provide greater translation to the clinic.
About MD Biosciences
MD Biosciences is a leading preclinical research group and contract research organization (CRO) working with biopharmaceutical and medical device companies in an effort towards progressing discovery and development programs to clinical stages. We are deeply focused on inflammatory, neurodegenerative/CNS, pain, dermal, metabolic and cardiovascular conditions with a particular emphasis on the interplay between the immune, nervous and cardiovascular systems and the conditions that arise in the cross talk between them. We bring decisive value to preclinical programs with the extensive experience gained over many years of handling different compound classes through all administration routes aimed at numerous therapeutic indications.
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