In the July 2009 issue

Selecting appropriate models for evaluating pain.
Pain-related Whitepapers .

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Selecting appropriate models for evaluating pain therapeutics.

Pain is an important clinical symptom that often indicates that there is something wrong such as tissue damage or disease. It is also a classical component of inflammation. We often use the pattern and presentation of the pain to chacterize and provide a diagnosis - but often the origin of pain can be misleading as in the case of referred pain where the pain exists in the area of the tissue damage as well as the skin surrounding the inner muscle or organ affected. Pain is mediated by a neural pathway of specific receptors, afferent nerved, CNA pathways etc and is relatively complex.

In vivo models provide valuable information and insights into pain mechanisms. There is a wide choice of models of pain ranging from acute to chronic with a variety of measurements available including relex withdrawls, spontaneous behaviors and operant behaviors. The choice of which model to use is critical as different mechanisms, pathways and processing may be involved. MD Biosciences offers a range of models of pain and can consult with a sponsor's team to determine the most appropriate model for the drug class being evaluated.

Pain Models

Speak with a scientist about evaluting a compound/device.

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Pain-related Whitepapers

Peripheral Nerve Injury: Understanding the mechanisms underlying neuropathic pain syndroms is crucial to the development of more effective therapies.

A new model of Post-Operative Pain: An optimal model for assessment of analgesic affects of various local treatment strategies such as new implants, patches, medical devices and creams.