pain models for neuropathic, nociceptive, inflammatory and post-operative pain

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Nociception | Preclinical Contract Research

Nociceptors are specialized sensory neurons that preferentially respond to noxious stimuli. Nociceptive or physiological pain refers to the type of pain that we feel on a day-to-day basis. It is directly associated with a noxious stimulus, such as bending our joints too far, and helps us put limits on ourselves to avoid damage. This information is mediated by both small unmyelinated fibers and myelinated fibers, and provides us with an awareness of the environment. Nociceptive pain is pharmacologically treatable.

MD Biosciences offers a wide range of pre-clinical contract research models for nociception that can be customized according to sponsors criteria. Models of Nociception are appropriate for evaluating the following drug classes:

  • Cannabinoid Receptor Agonists
  • FAAH Inhibition
  • apha2-adrenergic agonists 
  • opioids
  • TRPV1
  • Sodium Channel Blockers

Preclinical contract research for Nociception            Request Proposal
Model Tail Flick Visceral Capsaicin
Strain

ICR mice
SD rats

 ICR mice Balb/c mice
SD rats
Length Varies Varies 20 minutes
Positive Control Morphine Morphine Morphine
Measurements Latency time
Clinical signs		 # writhers
Clinical signs		 # Leg lifts
Clinical signs
Add-ons - - bleeds

 

Interesting Fact

According to an NIH statistics survey, the four most common types of pain are low back pain (27%), severe headache or migraine pain (15%), neck pain (15%), and facial pain (4%).

Client Testimonial

“Among all the CROs that I have used over the years, including recently for inflammation, MD Biosciences has been one of the very best in terms of scientific knowledge, expertise, data quality, timelines, flexibility and personal contacts.”

O.B., Director of Preclinical Research Pharmaceutical Company