Allergic asthma is typically triggered by allergens in the air such as pollen, mold, dust mites etc and is commonly characterized by reversible airway destruction, elevated levels of IgE causing mast cell activation, chronic airway inflammation and airway hyper-responsiveness (AHR). The immunological processes involved are characterized by proliferation and activation of Th2 lymphocytes, setting off an allergic cascade. Treatments currently available act by dampening inflammation or relaxing airways but do not alter underlying pathology and disease exacerbations still occur. These facts highlight the need for novel treatments, which in turn require suitable efficacy models.
This whitepaper discusses the events underlying the disease as well as standard readout options and corresponding data.